Study of Efficacy and Safety of Ginger Root Extract in Treatment of Patients with Low Back Pain

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Neonila Shuba
Tetiana Voronova
Tetiana Hambir

Abstract

The objective: to study efficacy and safety of treatment with herbal formulation of standardized extract of ginger root in patients with low back pain; to study impact of the formulation on the dynamics of inflammation process indices, hepatic and renal markers, purine, carbohydrate and lipid metabolism.


Patients and methods. The study involved 35 patients (28 women and 7 men) aged between 30 and 80 years with primary LBP syndrome. The treatment was provided using herbal formulation of standardized extract of ginger root at dose of 300 mg twice daily during two months. We evaluated efficacy of the formulation using VAS, Oswestry, Roland-Morris, McGill questionnaires. We analyzed effect of the drug product on cytokines levels (IL-1β, IGF-1), NO, CRP, ESR, metabolism indices (lipid, carbohydrate, liver function markers, uric acid levels).


Results. By the end of the study, in 2 months of the treatment, the VAS parameters had statistically significantly decreased from 55,71±2,98 mm to 23,17 mm±2,38, Oswestry parameters – from 16,66±1,09 to 8,69±1,06, McGill parameters – from 8,49±0,73 to 3,09±0,4, Roland-Morris parameters – from 5,37±0,54 to 2,22±0,33. We observed a statistically significant reduction in CRP, ESR, proinflammatory cytokines (IL-1β), free radical (NO), as well as cholesterol and glucose. The study did not demonstrate any dynamics in such laboratory parameters as bilirubin, ALT, AST, creatinine and uric acid.


Conclusions. Based on the study results we concluded that the standardized ginger root extract was effective and safe in treatment of patients with LBP. In the course of the treatment, the patients demonstrated reduction in pain intensity by 58%, life quality improvement by 48%, psycho-emotional state improvement by 59%, and vital activity improvement by 58%. We observed the anti-inflammatory effect of ginger root extract exerted by the drug product through degrading indices of CRP, ESR, proinflammatory cytokine IL-1β, and NO.

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How to Cite
Shuba, N., Voronova, T., & Hambir, T. (2016). Study of Efficacy and Safety of Ginger Root Extract in Treatment of Patients with Low Back Pain. Family Medicine, (4), 101–106. https://doi.org/10.30841/2307-5112.4.2016.248550
Section
Neurology
Author Biographies

Neonila Shuba, P. L. Shupyk National Medical Academy of Postgraduate Education, Kyiv City Clinical Hospital No 7

Neonila M. Shuba,

Department of Internal Medicine and Rheumatology at the P. L. Shupyk National Medical Academy of Postgraduate Education

Tetiana Voronova, P. L. Shupyk National Medical Academy of Postgraduate Education, Kyiv City Clinical Hospital No 7

Tetiana D. Voronova,

Department of Internal Medicine and Rheumatology at the P. L. Shupyk National Medical Academy of Postgraduate Education

Tetiana Hambir, P. L. Shupyk National Medical Academy of Postgraduate Education

Tetiana S. Hambir,

Department of Internal Medicine and Rheumatology

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