Is Renoprotection Real for Patients with Hyperuricemia?


Liudmyla Khimion
Oleksandr Burianov
Iryna Nayshtetik
Svitlana Rotova
Svitlana Smiyan
Svitlana Danylyuk
Nataliia Kicha
Tetiana Sytyuk
Tetiana Lebedeva
Viktoria Trophanchuk


Number of patients with progressive chronic kidney disease (CKD) is increasing all over the world. One of the risk factors for CKD development and progression is increased serum uric acid (sUA) level. Possibly, control of hyperurcemia with urate lowering therapy drugs can slow the decline in kidney function.

The objective: to determine efficacy and safety of allopurinol and febuxostat in treatment of patients with CKD and hyperurcemia to reduce the sUA level and analyze its influence on glomerular filtration rate (GFR).

Materials and methods. The study included 45 CKD patients (stages 3b-5) without other severe/decompensated diseases and contraindications to the allopurinol/febuxostat. All patients underwent a comprehensive clinical and laboratory examination, and were divided into the study groups: Group I (28 patients, 61.3±3.2 y.o., CKD3b-12, CKD4-10, on hemodialysis-6 patients) received febuxostat, Group II (24 patients, 60.7Ѓ}4.1 y.o., CKD3b-9, CKD4-10, on hemodialysis – 5 patients) took allopurinol.

Results. Achievement of the target level of sUA was significantly often registered in Group I: after 1 month – in 45.5% (in group II – in 15.9%, p<0.001); after 3 months – in 67.5% (in group II – 21.2% p<0.01); after 6 months, these figures were 90% and 37.1%, respectively (p<0.01). sUA level <300 μmol/l was accompanied by significant positive GFR changes in group I patients; in group II there was a gradual progression of GFR deterioration in 31.8% of patients.

Conclusions. In patients with pre-dialysis stages of CKD febuxostat demonstrates renoprotective abilities. Use of febuxostat in patients with CKD stage 3b-4 and in patients on hemodialysis is safe and more effective for target sUA level achievement than the use of allopurinol.


How to Cite
Khimion, L., Burianov, O., Nayshtetik, I., Rotova, S., Smiyan, S., Danylyuk, S., Kicha, N., Sytyuk, T., Lebedeva, T., & Trophanchuk, V. (2022). Is Renoprotection Real for Patients with Hyperuricemia?. Family Medicine, (1-2), 25–30.
For practicing physicians
Author Biographies

Liudmyla Khimion, P. L. Shupyk National Healthcare University of Ukraine

Liudmyla V. Khimion,

Department of Family Medicine

Oleksandr Burianov, Bogomolets National Medical University

Oleksandr A. Burianov,

Head of Department of Traumatology and Orthopedics

Iryna Nayshtetik, Clinic of Modern Rheumatology

Iryna M. Nayshtetik

Svitlana Rotova, P. L. Shupyk National Healthcare University of Ukraine

Svitlana О. Rotova,

Department of Nephrology and Renal Replacement Therapy

Svitlana Smiyan, I. Horbachevsky Ternopil National Medical University

Svitlana I. Smiyan,

Department of Internal Medicine No 2

Svitlana Danylyuk, P. L. Shupyk National Healthcare University of Ukraine

Svitlana V. Danylyuk,

Department of Family Medicine

Nataliia Kicha, P. L. Shupyk National Healthcare University of Ukraine

Nataliia V. Kicha,

Department of Family Medicine

Tetiana Sytyuk, P. L. Shupyk National Healthcare University of Ukraine

Tetiana O. Sytyuk,

Department of Family Medicine

Tetiana Lebedeva, Kyiv Regional Clinical Hospital

Tetiana O. Lebedeva

Viktoria Trophanchuk, Kyiv Regional Clinical Hospital

Viktoria V. Trophanchuk


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