The Fetal Diaphragmatic Hernia, Diagnosis and Therapy

##plugins.themes.bootstrap3.article.main##

Petro Veropotvelyan
Mykola Veropotvelyan
Alla Bondarenko
Svitlana Zhuravleva

Abstract

 The objective. early prenatal diagnosis signs of the congenital fetal diaphragmatic hernia determination by using ultrasound.


Patients and мethods. 46 publications analysis by Ukrainian and foreign researchers.


Results. The ultrasound diagnosis of the diaphragmatic hernia at 24–26 weeks of gestation dependends on the damaged side and a copathology presence (in 60–70%).


Conclusion. A co-pathology, intrathoracic liver location, lungs hypoplasia degree and heart compression index are main predictive signs which correlate with fetal survival.

##plugins.themes.bootstrap3.article.details##

How to Cite
Veropotvelyan, P., Veropotvelyan, M., Bondarenko, A., & Zhuravleva, S. (2016). The Fetal Diaphragmatic Hernia, Diagnosis and Therapy. Family Medicine, (4), 128–133. https://doi.org/10.30841/2307-5112.4.2016.248586
Section
Obstetrics and gynecology
Author Biographies

Petro Veropotvelyan, Interregional Center of Medical Genetics and Prenatal Diagnosis, Kryvyi Rih

Petro M. Veropotvelyan,

Head of the Office of Reproductive Function Pathology

Mykola Veropotvelyan, Interregional Center of Medical Genetics and Prenatal Diagnosis, Kryvyi Rih

Mykola P. Veropotvelyan,

Chief Medical Officer

Alla Bondarenko, Interregional Center of Medical Genetics and Prenatal Diagnosis, Kryvyi Rih

Alla O. Bondarenko,

Head of the Clinical Department of Ultrasound, Functional Prenatal Diagnosis and Fetal Medicine

Svitlana Zhuravleva, Interregional Center of Medical Genetics and Prenatal Diagnosis, Kryvyi Rih

Svitlana A. Zhuravleva

References

Deprest J. Antenatal prediction of lung volume and in-utero treatment by fetal endoscopic tracheal occlusion in severe isolated congenital diaphragmatic hernia / A.Flemmer, E.Gratacos, K.Nicolaides // Semin. Fetal Neonatal Med. 2009; 14(1): 8-13.

Deprest J. The making of fetal surgery /A. Flake, E. Gratacos, Y. Ville, K. Hecher, K. Nicolaides [et al.] // Prenat. Diagn. 2010; 30(7): 653-67.

Ruano R. A randomized controlled trial of fetal endoscopic tracheal occlusion versus postnatal management of severe isolated congenital diaphragmatic hernia / C.T. Yoshisaki, M.M. Da Silva, M.E.J. Ceccon, M.S. Grasi, U. Tannuri [et al.] // Ultrasound Obstet. Gynecol. 2012; 39(1): 20-7.

Jani J. Fetal surgery for severe congenital diaphragmatic hernia? / K.H. Nicolaides // Ultrasound Obstet. Gynecol. 2012; 39(1): 7-9.

Harrison M.R. A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia / R.L. Keller, S.B. Hawgood, J.A. Kitterman, P.L. Sandberg, D.L. Farmer [et al.] // N. Engl. J. Med. 2003; 349 (20): 1916-24.

Ruano R. Early fetoscopic tracheal occlusion for extremely severe pulmonary hypoplasia in isolated congenital diaphragmatic hernia: preliminary results / J.L. Peiro, M.M. Da Silva, J.A. Campos, E. Carreras, U. Tannuri [et al.] // Ultasound Obstet. Gynecol. 2013; 42 (1): 70-6.

Dorzhiyev B.D. The early antenatal diagnostic and treatment of congenital diaphragmatic hernia on materials of children’s surgical department of city clinical hospital of emergency medical care, 2001–2005 // Byuleten Skhidno-Sybirskoho naukovoho tsentru RAMN. 2011, № 4 (80), ch.2.

Isakov Y.F., Volodin N.N., Geraskin A.V. Neonatal Surgery. – M.: Dynasty; 2011: 332-58.

Demidov V.N. Congenital diaphragmatic hernia fruit – the possibilities of ultrasound diagnosis and prediction of postnatal outcome / N.V. Mashinets, J.L. Podurovskaya, A.A. Burov // Obstetrics and gynecology. 2014; 4: 38-45.

Mashinets N.V. Ultrasound diagnosis of congenital diaphragmatic hernia in a fetus predicting postnatal outcome / V.N. Demidov, J.L. Podurovskaya, A.A. Burov // Prenatal diagnosis. 2013; 12 (3): 228-36.

Mashinets N.V. Fetal diaphragmatic hernia (diagnosis, treatment, postnatal outcomes) // Journal of Obstetrics and Gynecology. 2016; 2: 20-26.

Belozertseva I.V. Diaphragmatic hernia: Features of diagnostics / S.G. Gadetskaya, S.I. Nikolenko, I.A. Bezuglova, T.Y. Denisenko // Child Health. 2012; 5 (40).

Achiron R. Three- and four-dimensional ultrasound: new methods for evaluating fetal thoracic anomalies / Y. Gindes, Y. Zalel [et al.] // Ultrasound Obstet Gynecol. – 2006; V. 27. 128-133.

Peralta C. Lung and heart volumes by three-dimensional ultrasound in normal fetuses at 12–32 weeks’ gestation / P. Cavoretto, S. Csapo, O. Falcon, K. Nikolaides // Ultrasound Obstet. Gynecol. 2008; V. 32. – P. 36-43.

Spaggiari E. Prognostic value of a hernia sac in congenital diaphragmatic hernia / J. Stirnemann, J.P. Bernard, L. De Saint Blanquat, S. Beaudoin, Y. Ville // Ultrasound Obstet. Gynecol. 2013; 41 (3): 286-90.

Doné E. Prenatal diagnosis, prediction of outcome and in utero therapy of isolated congenital diaphragmatic hernia / L. Gucciardo, T.V. Mieghem, J. Jani, M. Cannie, D.V. Schoubroeck [et al.] // Prenat. Diagn. 2008; 28 (7): 581-91.

Gucciardo L. Prediction of outcome in isolated congenital diaphragmatic hernia and its consequences for fetal therapy. / J. Deprest, E. Doné, T. Van Mieghem, M. Van de Velde, E. Gratacos [et al.] // Best Pract. Res. Clin. Obstet. Gynecol. 2008; 22(1): 123-38.

Gallot D. Prenatal detection and outcome of congenital diaphragmatic hernia: a French registry-based study / C. Boda, S. Ughetto, I. Perthus, E. Robert-Gnansia, C. Francannet [et al.] // Ultrasound Obstet. Gynecol. 2007; 29 (3): 276-83.

Ruano R. Congenital heart anomaly in newborns with congenital diaphragmatic hernia: a single-center experience / P. Javadian, J.A. Kailin, S.A. Maskatia, A.A. Shamshirsaz, D.L. Cass [et al.] // Ultrasound Obstet. Gynecol. 2015; 45 (6): 683-88.

Judah E.V. Lehkye. In: Medvedev MV, red. Prenatalnaya sonography. – M.: Realnoe Time; 2005: 341-71.

Enns G.M. Congenital diaphragmatic defects and associated syndromes, malformations and chromosome anomalies: a retrospective study of 60 patients and literature review / V.A. Cox, R.B. Goldstein, D.L. Gibbs, M.R. Harrison, M. Golabi // Am. J. Med. Genet. 1998; 79 (3): 215-25.

Pober B.R. Overview of epidemiology, genetics, birth defect, and chromosome abnormalities associated with CDH // Am. J. Med. Genet. Part C. Semin. Med. Genet. 2007; 145C(2): 158-71.

Geary M.P. Perinatal outcome and prognostic factors in prenatally diagnosed congenital diaphragmatic hernia / L.S. Chitty, J.J. Morrison, V. Wright, A. Pierro, C.H. Rodeck // Ultrasound Obstet. Gynecol. 1998; 12(2): 107-11.

Jani J.C. Antenatal ultrasound prediction of pulmonary hypoplasia in congenital diaphragmatic hernia: correlation with pathology / A.G. Cordier, J. Martinovic, C.F. Peralta, M.V. Senat, V. Segers [et al.] // Ultrasound Obstet. Gynecol. 2011; 38(3): 344-9.

Jani J. Prenatal prediction of survival in isolated left-sided diaphragmatic hernia / R.L. Keller, A. Benachi, K.H. Nicolaides, R. Favre, E. Graracos [et al.] // Ultrasound Obstet. Gynecol. 2006; 27 (1): 18-22.

Ruano R. Prediction and probability of neonatal outcome in isolated congenital diaphragmatic hernia using multiple ultrasound parameters / E. Takashi, M.M. Da Salva, J.A. Campos, U. Tannuri, M. Zugaib // Ultrasound Obstet. Gynecol. 2012; 39 (1): 42-49.

Mullassery D. Value of liver herniation in prediction of outcome in fetal congenital diaphragmatic hernia: a systematic review and meta-analysis / M.E. Ba’ath, E.C. Jesudason, P.D. Losty // Ultrasound Obstet. Gynecol. 2010; 35(5): 609-14.

Eroglu D. Prenatal diagnosis of bilateral diaphragmatic hernia by fetal sonography / F. Yanik, A.E. Sakallioglu, U. Arikan, B. Varan, E. Kuscu // J. Obstet. Gynecol. Res. 2006; 32(1): 90-3.

Song M.S. Bilateral congenital diaphragmatic hernia: diagnostic clues at fetal sonography / S.J. Yoo, J.F. Smallhorn, J.B. Mullen, G. Ryan, L.K. Hornberger // Ultrasound Obstet. Gynecol. 2001; 17(3): 255-8.

Rais-Bahrami K. Bilateral congenital agenesis / D. Hsiao, B. Short, S. Baumgart // J. Neonatal Perinat. Med. 2008; 1(1): 59-62.

Demidov V.N. Sonography of the fetus. The pathology of the gastrointestinal tract, hernias of the abdominal wall and diaphragm / N.V. Mashinets. – M.: BINOM; 2014: 134 p.

Heling K.S. Reliability of the lung-to-head ratio in predicting outcome and neonatal ventilation parameters in fetuses with congenital diaphragmatic hernia / R.R. Wauer , H. Hammer et al // Ultrasound Obstet Gynecol. 2005 Feb; 25 (2): 112-8.

Sharland G.K. Coarctation of the aorta: difficulties in prenatal diagnosis / K.Y. Chan, L.D. Allan // Br Heart J. 1994 Jan; 71(1): 70-75.

Jani J. Observed to expected lung area to head circumference ratio in the prediction of survival in fetuses with isolated diaphragmatic hernia / K.H. Nicolaides, R.L. Keller, A. Benachi, C.F. Peralta, R. Favre [et al.] // Ultrasound Obstet. Gynecol. 2007; 30 (1): 67-71.

Kitano Y. Re-evaluation of stomach position as a simple prognostic factor in fetal left congenital diaphragmatic hernia: a multicenter survey in Japan / H. Okuyama, M. Saito, N. Usui, N. Morikawa, K. Masumoto [et al.] // Ultrasound Obstet. Gynecol. 2011; 37(3): 277-82.

Jani J.С. Lung-to-head ratio to unify the technique / C.F.A. Peralta, K.H. Nicolaides // Ultrasound Obstet. Gynecol. 2012; 39(1): 2-6.

Walsh D.S. Assessment of fetal lung volumes and liver hernitation with magnetic resonance imaging in congenital diaphragmatic hernia / A.M. Hubbard, O.O. Oluttoye, L.J. Howell, T.M. Crombleholme, A.W. Flake [et al.] // Am. J. Obstet. Gynecol. 2000; 183(5): 1067-9. 10.1067/mob.2000.108895

Kitano Y. Liver position in fetal congenital diaphragmatic hernia retains a prognostic value in the era of lung-protective strategy / S. Nakagawa, T. Kuroda, T. Honna, Y. Itoh, T. Nakamura [et al.] // J. Pediatr. Surg. 2005; 40(12): 1827-32.

Cannie M. Quantification of intrathoracic liver herniation by magnetic resonance imaging and prediction of postnatal survival in fetus with congenital diaphragmatic hernia / J. Jani, C. Chaffiotte, P. Vaast, P. Deruelle, V. Houfflin-Debarge [et al.] // Ultrasound Obstet. Gynecol. 2008; 32(5): 627-32.

Worley K.С. Fetal magnetic resonance imaging in isolated diaphragmatic hernia: volume of liver and neonatal outcome / J.S. Dashe, R.G. Barber, S.M. Megison, D.D. McIntire, D.M. Twickler // Am. J. Obstet. Gynecol. 2009; 200(3): 318. e1-318. e6.

Langwieler T. The relationship of diaphragmatic defect, liver growth, and lung hypoplasia in nitrofen-induced congenital diaphragmatic hernia in the rat / H.C. Fiegel, M. Alaamian, O. Mann, I. Beshir, J.R. Izbicki [et al.] // Pediatr. Surg. Int. 2004; 20(7): 509-14.

Metkus A.P. Sonographic predictors of survival in fetal diaphragmatic hernia / R.A. Filly, M.D. Stringer, M.R. Harrison, N.S. Adzick // J. Pediatr. Surg. 1996; 31(1): 148-51.

Metkus A.P. Assessment of lung area in normal fetuses at 12–32 weeks / C.F.A. Peralta, P. Cavoretto, B. Csapo, H. Vandecruys, K.H. Nicolaides // Ultrasound Obstet. Gynecol. 2005; 26(7): 718-24.

Deprest J. Deliberately delayed and shortened fetoscopic tracheal occlusion – a different strategy after prenatal diagnosis of life-treatening congenital diaphragmatic hernias [author reply] / J. Jani, E. Gratacos, K. Nicolaides, S. Nelson; The FETO Task Group. // J. Pediatr. Surg. 2006; 41: 1345-6.

Spaggiari E. Prenatal prediction of pulmonary hypertension in congenital diaphragmatic hernia / J.J. Stirnemann, P. Sonigo, N. Khen-Dunlop, L. De Saint Blanquat, Y. Ville // Ultrasound Obstet. Gynecol. 2015; 45(5): 572-7.

Demidov V.N. A method of prenatal prediction of neonatal condition with congenital diaphragmatic hernia // N.V. Mashinets, Y.I. Kucherov, Y. Zhirkovа, AA. Burov // FGBI «NTsAGiP them. Kulakov, «the Ministry of Health and Social Development of the Russian Federation. N 2011139531/14; Publ. 02.27.2013, Bull. N 6.