Influence of the Plant-citrate Complex on Indicators of Systemic Inflammation in Patients with Urolithiasis

##plugins.themes.bootstrap3.article.main##

Olena Karpenko
Anna Petrova

Abstract

Treatment of urolithiasis is a complex task of modern medicine. The search for non-invasive methods of treatment, prevention of relapses and complications, slowing down the development of renal failure is an urgent issue of our time. The study demonstrated a comprehensive analysis of indicators of systemic inflammation in patients with urolithiasis and the effectiveness of using the plant-citrate complex.


The objective: to conduct a clinical assessment of systemic inflammation in patients with urolithiasis, to determine the effectiveness of the use of the plant-citrate complex of the drug Uriklar on the indicators of systemic inflammation.


Materials and methods. There were examined 52 (55.6 %) patients with urolithiasis, which were divided into two groups: Group I (main group) – 32 patients with urolithiasis who received the herbal citrate complex and Group II (comparison group) – 20 patients with urolithiasis. The control group included 20 almost healthy individuals. All patients underwent clinical and laboratory tests: general and biochemical blood tests to determine the parameters of iron metabolism, lipid profile, CRP, determination of the levels of cytokines in the blood, blood pressure, body mass index.


Results. The results of this study demonstrate the development of systemic inflammation in patients with urolithiasis, determined by a decrease in GFR. Against the background of the treatment with Uriklar, a decrease in the levels of pro-inflammatory cytokines, CRP and ferritin is observed, which indicates the anti-inflammatory properties of the drug.


Conclusion. Such properties of the plant-citrate complex are pathogenetically substantiated and can be recommended for urolithiasis, which, along with the therapeutic properties, allows to obtain the provision of metaphylaxis of urolithiasis and to slow down the rate of development of chronic kidney disease.

##plugins.themes.bootstrap3.article.details##

How to Cite
Karpenko, O., & Petrova, A. (2021). Influence of the Plant-citrate Complex on Indicators of Systemic Inflammation in Patients with Urolithiasis. Family Medicine, (5-6), 41–46. https://doi.org/10.30841/2307-5112.5-6.2020.225332
Section
For practicing physicians
Author Biographies

Olena Karpenko, Kyiv City Center of Nephrology and Dialysis, Bogomolets National Medical University

Olena V. Karpenko,

Department of Propedeutics of Internal Medicine No 2

Anna Petrova, Kyiv City Center of Nephrology and Dialysis, Bogomolets National Medical University

Anna S. Petrova,

Department of Propedeutics of Internal Medicine No 2

References

Бачурін Г.В., Коломоєць Ю.С. Діагностично-прогностична роль цитокінів, інтерлейкінів та біомаркерів раннього пошкодження нирок у хворих на сечокам’яну хворобу // Український науково-практичний журнал урологів, андрологів та нефрологів. – 2019. – С. 247–242.

Захарова Н.Б., Гражданов Р.А., Понукалин А.Н., Иноземцева Н.Д., Россоловский А.Н. Диагностическое значение про- и противовоспалительных цитокинов в моче при обострении хронического калькулезного пиелонефрита / Заочная конференция «Актуальные проблемы фундаментальной и клинической уронефрологии 2013» Урология. Оригинальная статья // Бюллетень медицинских Интернет-конференций. – 2013. – Т. 3, № 4.

Железникова Г.Ф. Цитокины как предикторы течения и исхода инфекций // Цитокины и воспаление. – 2009. – № 8 (1). – С. 10–17.

Кудряшова И.П., Оспельникова Т.П., Ершов Ф.И. Динамика показателей цитокинового профиля при хроническом пиелонефрите. // Клиническая нефрология. – 2012. – № 3. – С. 39–41.

Малышев М.Е., Бельских О.А., Сорокина А.А., Зубор О.И. Информативность показателей цитокинового профиля сыворотки крови и слюнной жидкости у больных хроническими болезнями почек // Курский практический вестник «Человек и его здоровье», 2016. – № 1. – С. 44–49.

Патофізіологія нирок за нефролітіазу / Бойчук Т.М., Роговий Ю.Є., Андрійчук О.І. Чернівці: Буковина друк, 2018. – 193 с.

Фрейдлин И.С. Паракринные и аутокринные механизмы цитокиновой иммунорегуляции // Иммунология. – 2001. – № 5. – С. 47.

Эндотелиальная дисфункция у больных мочекаменной болезнью / П.В. Глыбочко, А.А. Свистунов, А.Н. Россоловский и др. // Урология. – 2010. – № 3. – С. 3–6.

Amore A., Coppo R. Immunological basis of inflammation in dialysis // Nephrol Dial Transplant. – 2002. – Vol. 17, Suppl 8. – Р. 16–24.

Franceschi С., & Campisi J. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Advances in geroscience: Impact on healthspan and chronic disease perspective, 69, 4–6.

Stenvinkel P., Ketteler M., Johnson R.J., Lindholm B., Pecoits-Filho R., Riella M., Heimbürger O., Cederholm T., Girndt M. IL-10, IL-6, and TNF-alpha: central factors in the altered-cytokine network of uremia the good, the bad, and the ugly // Kidney Int. – 2005. – Vol. 67, № 4. – Р. 1216–1233.

Stringer S, Sharma P., Dutton M., Jesky M., Ng K., Kaur O., Chapple I., Dietrich T., Ferro C., Cockwell P. The natural history of, and risk factors for progressive Chronic Kidney Disease (CKD): the Renal Impairment in Secondary care (RIISC) study; rationale and protocol // BMC Nephrology. – 2013. – 1495 р. – doi: 10.1186/1471-2369-14-95.

Taha A.S. Urinalysis for interleukin-8 in the non-invasive diagnosis of acute and chronic inflammatory diseases. Crosshouse Hospital, Scotland, UK // Postgrad Med. J. – 2003. – Vol. 79. – P. 159–1.

Tikhonov I, Rebenok A, Chyzh A. // A study of interleukin-8 and defensins in urine and plasma of patients with pyelonephritis and glomerulonephritis. Nephrol Dial Transplant. – 1997. – Dec. 12(12). – P. 2557–61.

Wong W., Singh A.K. Urinary cytokines: clinically useful markers of chronic renal disease progression? Current Opinion in nephrology and hypertension. – 2001. – Vol. 6. – P. 807–811.