Effect of S-ademethionine on Arginine Content and Its Metabolites in Patients with Chronic Lymphocytic Leukemia During Chemotherapy
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Abstract
The objective: to investigate the nature of changes in arginine and its metabolites in the dynamics of S-ademethionine administration on the background of program chemotherapy (CT) in patients with B-cell chronic lymphocytic leukemia (B-CLL).
Materials and methods. 26 patients with B-CLL were examined. Depending on the inclusion of S-ademethionine in therapy, patients were divided into two groups: I (n=12) – patients with B-CLL, who received CT; II (n=14) – patients with B-CLL, who on the background of CT was treated with S-ademethionine 1000 mg/day intravenously for 10 days, then 1000 mg/day orally for 18 days. Assessment was performed twice: before the CT started and after 2 courses of CT. The content of arginine, citrulline, arginase activity, ornithine decarboxylase (ODC) in the blood serum was investigated.
Results. Holding CT for patients with B-CLL with inclusion of concomitant therapy with S-ademethionine can increase the arginine level in 1.2 times (p=0.01), the ODC activity – 28 times (p=0.001) and decrease the arginase activity in 1,4 times (p=0.01), the citrulline content – 7.9 times in the blood serum (р=0.0001).
Conclusion. In patients with B-CLL, the appointment of S-ademethionine on the background of CT can reduce the manifestations of arginine/citrulline cycle disorders caused by oncohematological disease.
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