Neuroimaging Characteristic of Structural Disorders of the Brain and Cerebrospinal Fluid Spaces in Patients with Chronic Cerebral Ischemia
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Abstract
The objective: to evaluate the neuroimaging markers of structural disorders of the brain and cerebrospinal fluid spaces in patients with chronic cerebral ischemia (CHEM) on the background of multifocal atherosclerosis.
Materials and methods. The study enrolled 137 patients aged 40 to 84 years with chemotherapy with multifocal atherosclerosis. Patients were divided into three clinical groups depending on the localization of vascular pool lesions with stenosing atherosclerosis. Patients underwent qualitative and quantitative assessment of focal and diffuse changes in the substance of the brain and cerebrospinal fluid spaces.
Results. According to the frequency of detection among structural changes in the brain in patients with different variants of the combination of vascular pools affected by atherosclerosis, mild leukoaraiosis (61.3% from 97.1%) and mixed cerebral atrophy (74.5%) prevailed. Lacunar focal changes in CHEM were found in half of the cases (51.8%), including in the clinical group I in 36.7% of cases, in the second group in 56.3%, in the III group in 55.0 % Single lacunar foci in the general group of patients prevailed over numerous 2.7 times (37.9% versus 13.9%; p<0.001). More often, lacunar foci were territorially cortical (in 24.1% of cases) than subcortical (in 2.9% of cases; p <0.001). Most patients with CHM have found a combination of several MR markers of structural brain damage.
Conclusion. In patients of all age groups with chronic cerebral ischemia (CHEM), structural brain lesions were established based on the determination of various MR markers: white matter hypertension (leukoaraiosis – 97.1%), cerebral atrophy (74.4%), lacunar infarction (51, 8%), territorial postinfarction foci (56.2%). The multifocal nature of vascular lesion, comorbidity, and multifactoriality affect the heterogeneity and severity of structural brain disorders that determine the course of chemotherapy.##plugins.themes.bootstrap3.article.details##
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