Assessment of effectiveness and acceptability of combination of L-carnitine and arginine hydrochloride in patients with stable effort angina
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Abstract
The objective: to assess the effectiveness and acceptability of combination of L-carnitine and arginine hydrochloride in patients with CHD with stable effort angina.
Materials and methods. There were examined 63 patients with stable effort angina of II – III functional classes in the age of (56,7±2,3 years old). There was assessed the clinical course of the disease at the beginning and at the end of the therapy the month later. There were performed 24-hour monitoring ECG and veloergometry, was studied the function of endothelium with the use of Doppler sonography of shoulder joint. Patients were divided into two groups. Patients of the main group (n=32) against the background of basic therapy of stable angina were receiving the combination of L-carnitine and arginine hydrochloride. Patients of comparison group (n=31) received only the standard basic therapy.
Results. During the research there is noted the improvement of patients’ lives, as evidenced by decrease of subjective complaints expressiveness, decrease of anginose episodes, reduction of running length of ischemia per day according to the data of 24-hour monitoring ECG is reliably more expressed in main group of patients. According to the data of veloergometry the employment of combined therapy contributed to the significant increase of parameters of tolerance to physical activity and the decrease of functional class of angina in relation to comparison group. Combination of L-carnitine and arginine hydrochloride reliably improves the endothelium-dependent vasodilation after treatment (p<0,05). There is registered the 50,9% increase of such state in generally within the group, 33,0% increase – in patients with stable effort angina II FG and 64,8% – III FG.
Conclusion. The data that we received illustrates that application of metabolically active combination of L-carnitine and arginine hydrochloride against the background of basic therapy in patients with stable angina leads to statistically reliable decrease of average number of anginose episodes and daily maintenance of nitroglycerin; leads to increase of physical load tolerance and improves the endothelium function relatively to the group of patients that had only basic therapy.
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