Determination of the Factors of Onset of Cardiovascular Death in Patients Under the Age of 80 in Elderly Patients with Coronary Heart Disease

Abstract

The objective: detection and analysis of factors that reduce the life of patients with coronary heart disease (CHD).

Materials and methods. A retrospective assessment of the history of the illnesses of 196 patients with coronary heart disease was performed, and there was a hospital treatment in the cardiology department of the State University «Institute of Gerontology named after D.F. Chebotareva NAMNU» for the period from 1997–2017 and reached the end point. All the subjects were hospitalized for the first time and subsequently were observed with the main diagnosis of coronary heart disease: stable angina pectoris I–III FK. The diagnosis of the underlying disease was established on the basis of general clinical examinations and special instrumental and laboratory methods in accordance with current guidelines for the diagnosis of coronary heart disease at the stage of examination of patients. Patient monitoring lasted from 5 to 20 years. Cardiovascular death was taken as the end point.

Results. Patients with chronic coronary heart disease who had not reached the age of 80 had a high incidence of major CVD factors: hypertension, 100%, 17% DM, 42,2% smoking, 80% hypercholesterolemia, than in patients who had survived to 80 years of age. Patients of the examined groups significantly differed in vascular and endothelial function, as indicated by PM at the peak of reactive hyperemia in patients of the first group was 5,05±0,8 ml/min*100, the second group was 7,7±0,98 ml/min*100 (p<0,05), respectively, indicating a pronounced endothelial dysfunction in patients in group 1.

Conclusion. The study of the prevalence of CVD factors in different groups showed that patients in Group 1 had a high incidence of CWR major factors. At the same time, for group 1, the life span effect on life expectancy has a level of glucose, PM poppy, FV, spontaneous aggregation. For persons who have reached the age of 80 years and older, CVV risk factors have not been significantly associated with life expectancy.