С-reactive Protein and Its Role in Pathogenesis of Heart Disorders (Literature Review and Own Data)
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Abstract
C-reactive protein is a criterion of inflammation and a significant marker of cardiovascular risk.
The objective: to estimate condition of problem of CRP usage according to the literature and own data.
Matherials and methods. We held a literature review in Pubmed database and domestic sources. We also analyzed data of 75 patients with hemorrhagic vasculitis, divided into groups according to gallbladder (GB) condition. Data was processed using Statistica 6.0 software.
Results. CRP was crystallized in 1947 by Maclyn McCarty, who proposed to use it for control of rheumatism course. CRP is a nonspecific acute phase protein, which is synthesized in liver during inflammation. Main function of CRP is to eliminate pathogens and endotoxins. CRP level can vary between <1,0 mg/L and 1000 times bigger values. CRP is studied as a marker of infection, inflammation and tissue damage in ischemic heart disease, stroke, cognitive disorders, cardiovascular death. High level of CRP is associated with increase of caediovascular morbidity and mortality. In our patients with hemorrhagic vasculitis mean level CRP was 7,51±1,22 mg/L, which is almost twice bigger than the normal values. This can suggest a high cardiovascular risk. CRP level was maximal in cholelithiasis and cholecystectomy groups. Independently of GB condition CRP correlated with left atrium size and acute phase parameters of blood.
Conclusions. According to the literature, CRP eliminates pathogens, endotoxins, necrotized cells. In patients with hemorrhagic vasculitis CRP directly correlated with inflammation parameters and left atrium size, indirectly – with anemic syndrome. CRP level was dependent of GB condition, being the highest in groups with cholelithiasis and prior cholecystectomy.##plugins.themes.bootstrap3.article.details##
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References
С-реактивний білок як показник системних і легеневих запальних процесів у хворих на хронічне обструктивне захворювання легень / Фещенко Ю.І., Панасюкова О.Р., Рекалова О.М. та ін. // Астма і алергія. – 2011. – №1. – С. 23-26.
Радченко Л.М. Кореляційні зв’язки між С-реактивним протеїном та антистрептолізином-О / Л.М. Радченко // Матер. 70 міжнарод. науково-практичної конференції молодих вчених «Актуальні проблеми клінічної, експериментальної, профілактичної медицини, стоматології та фармації» Донецьк, 2008. – С.117.
Analysis of serum ferritin and high sensitive C reactive protein in patients with gout. [Article in Chinese] / J. Wei, H. Zhang, Y. Wang [et al.] // Wei Sheng Yan Jiu. 2017 Mar;46(2):232-236.
Association between diet, lifestyle, metabolic cardiovascular risk factors, and plasma C-reactive protein levels / G.N. Fredrikson, B. Hedblad, J.A. Nilsson [et al.] // Metabolism. 2004;53:1436–1442.
Association between the circulating leptin levels and the biomarkers of oxidative stress and inflammation among Iranian overweight and obese adults / N. Aboutaleb, M. Zarrati, E. Cheshmazar [et al.] // Med J Islam Repub Iran. 2017; 31: 81. doi: 10.14196/mjiri.31.81
Associations of dietary fiber intake with long-term predicted cardiovascular disease risk and C-reactive protein levels (from the National Health and Nutrition Examination Survey Data [2005–2010]) / H. Ning, L. Van Horn, C.M. Shay [et al.] // Am J Cardiol. 2014;113:287–291.
Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middleaged and older Chinese people / Z. Yu, X. Ye, J. Wang J [et al.] // Circulation. 2009;119:2969–2977.
C-reactive protein and alcohol consumption: Is there a U-shaped association? Results from a populationbased study in Russia. The Arkhangelsk study / M. Averina, O. Nilssen, V.L. Arkhipovsky [et al.] // Atherosclerosis. 2006;188:309–315.
C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (monitoring trends and determinants in cardiovascular disease) Augsburg cohort study, 1984 to 1992 / W. Koenig, M. Sund, M. Fröhlich [et al.] // Circulation. 1999;99(2):237–242.
C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity / D. Gershov, S. Kim, N. Brot [et al.] // J Exp Med. 2000;192(9):1353-1364.
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis / Emerging Risk Factors Collaboration, S. Kaptoge, E. Di Angelantonio [et al.] // The Lancet. 2010;375(9709):132–140. doi: 10.1016/s0140-6736(09)61717-7.
C-reactive protein inhibits surviving expression via Akt/mTOR pathway downregulation by PTEN expression in cardiac myocytes / B.S. Lee, S.H. Kim, J. Oh [et al.] // PLoS One. 2014 May 27;9(5):e98113. doi: 10.1371/journal.pone.0098113. eCollection 2014.
C-reactive protein is a mediator of cardiovascular disease/ R.J. Bisoendial, S.M. Boekholdt, M. Vergeer [et al.] // Eur Heart J. 2010 Sep;31(17):2087-91. doi: 10.1093/eurheartj/ehq238. Epub 2010 Aug 3.
de Ferranti S.D. C-reactive protein: a nontraditional serum marker of cardiovascular risk / S.D. de Ferranti, N. Rifai // Cardiovasc Pathol. 2007;16:14–21.
Discordance between erythrocyte sedimentation rate and C-reactive protein measurements: clinical significance / K.H. Costenbader, L.B. Chibnik, P.H. Schur // Clin Exp Rheumatol. 2007;25(5):746-749.
Dowton S.B. Acute phase reactants in inflammation and infection / S.B. Dowton, H.R. Colten // Semin Hematol. 1988;25(2):84-90.
Elevated C-reactive protein levels in overweight and obese adults / M. Visser, L.M. Bouter, G.M. McQuillan [et al.] // JAMA. 1999;282:2131–2135.
Erythrocyte Sedimentation Rate and C-reactive Protein Measurements and Their Relevance in Clinical Medicine / C. Bray, L.N. Bell, H. Liang [et al.] // WMJ. 2016 Dec;115(6):317-21.
http://centennial.rucares.org/index.php?page=C-Reactive_Protein
Inflammatory Biomarkers and Risk of Atherosclerotic Cardiovascular Disease / E. Yu, H.Y. Hsu, C.Y. Huang [et al.] // Open Med (Wars). 2018 May 24;13:208-213. doi: 10.1515/med-2018-0032. eCollection 2018.
Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women’s Health Initiative observational study / A.D. Pradhan, J.E. Manson, J.E. Rossouw [et al.] // The Journal of the American Medical Association. 2002;288(8):980–987. doi: 10.1001/jama.288.8.980.
Litao M.K. Erythrocyte sedimentation rate and C-reactive protein: how best to use them in clinical practice / M.K. Litao, D. Kamat // Pediatr Ann. 2014;43(10):417-420.
Markanday A. Acute Phase Reactants in Infections: Evidence-Based Review and a Guide for Clinicians / A. Markanday // Open Forum Infect Dis. 2015;2(3):ofv098.
Obesity indices and metabolic markers are related to hs-CRP and adiponectin levels in overweight and obese females / Z. Sanip, F.D. Ariffin, B.A.M. Al-Tahami [et al.] // Obes Res Clin Pract. 2013;7(4):e315–e20.
Pepys M.B. C-reactive protein: a critical update / M.B. Pepys, G.M. Hirschfield // J Clin Invest. 2003;111(12):1805-1812.
Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death / C.M. Albert, J. Ma, N. Rifai [et al.] // Circulation. 2002;105(22):2595–2599. doi: 10.1161/01.CIR.0000017493.03108.1C.
Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis / H.-K. Kuo, C.-J. Yen, C.-H. Chang [et al.] // The Lancet Neurology. 2005;4(6):371–380. doi: 10.1016/s1474-4422(05)70099-5.
Relationship between cigarette smoking and novel risk factors for cardiovascular disease in the United States / L.A. Bazzano, J. He, P. Muntner [et al.] // Ann Intern Med. 2003;138:891–897.
Ridker P. M. C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: moving an inflammatory hypothesis toward consensus / P.M. Ridker // Journal of the American College of Cardiology. 2007;49(21):2129–2138. doi: 10.1016/j.jacc.2007.02.052.
Saturated fatty acids intake in relation to C-reactive protein, adiponectin, and leptin: a population-based study / S. Santos, A. Oliveira, S. Casal [et al.] // Nutrition. 2013;29:892–897.
Systemic low-grade inflammation is related to both circulating and adipose tissue TNFα, leptin and IL-6 levels in obese women / M. Maachi, L. Pieroni, E. Bruckert [et al.] // Int J Obes (Lond) 2004;28(8):993–7.
The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling / B. Bottazzi, A. Inforzato, M. Messa [et al.] // Journal of Hepatology. 2016;64(6):1416–1427. doi: 10.1016/j.jhep.2016.02.029
Tillett W.S. Serological Reactions in Pneumonia with a Non-Protein Somatic Fraction of Pneumococcus / W.S. Tillett, T.Jr. Francis // J Exp Med. 1930;52(4):561-571.
The influence of age, sex, and race on the upper reference limit of serum C-reactive protein concentration / M.H. Wener, P.R. Daum, G.M. McQuillan // J Rheumatol. 2000;27:2351–2359.
Xia D. Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxemia / D. Xia, D. Samols // Proc Natl Acad Sci USA. 1997;94(6):2575-2580.
