Method of Prediction the Development of Arterial Hypertension in Type 1 and 2 Diabetes
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Abstract
The objective: to create a mathematical model of prediction the development arterial hypertension in type 1 and type 2 diabetes based on traditional risk factors for cardiovascular diseases and the serum level of vascular endothelial factors.
Materials and methods. The study was attended by 97 people. We examined 33 type 1 diabetes patients: 23 hypertensive and 10 nonhypertensive. Also 64 type 2 diabetes patients: 41 hypertensive and 23 non-hypertensive. Were studied BMI, blood glucose, HbA1c, total cholesterol, HDL, LDL, triglycerides, insulin, HOMA, Caro, serum level of EMAP-II, fibronectin, VEGF, ICAM-1, VCAM-1, E-selectin by immunoenzyme assay in all patients. Endothelial-dependent dilatation was investigated by Celermajer metod. Static analysis was performed by metod of logistic regression.
Results. In type 1 diabetes patient, among 15 factors, 3 were selected that had a provocative effect on the development of arterial hypertension: blood glucose, EMAP-II, fibronectin. In type 2 diabetes patients, among 18 factors, 5 were identified, the combination of which had a provocative effect on the development of arterial hypertension: BMI, HbA1c, triglycerides, ICAM-1, endothelial-dependent dilatation. A computer program «Estimation of prediction the development arterial hypertension in diabetes mellitus» has been launched based on the obtained mathematical formulas.
Conclusion. A computer program «Estimation of prediction the development arterial hypertension in diabetes mellitus» and mathematical models, which formed the basis for it, allow identifying risk factors for arterial hypertension in type 1 and type 2 diabetes patients. Early started preventive work, continuous monitoring of risk factors helps prevent the development of arterial hypertension in these patients.##plugins.themes.bootstrap3.article.details##
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