Features of autonomic dysfunction in the patients with Parkinson’s disease on the background of autoimmune pathology
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Abstract
Dysautonomia is a common occurrence in PD and is probably due to the neurodegenerative disease process itself, taking place inside either the CNS or peripheral postganglionic neurons.
The objective: to investigate the clinical manifestations of autonomic disorders in the patients with PD on the background of autoimmune thyroiditis (AIT).
Materials and methods. 109 patients with PD at the age from 47 to 75 years were examined. The main group of patients consisted of ІА and ІB subgroups, control group – ІІА and IIB. Conducted general clinical and neurological examination, assessment of motor functions using the unified PD rating scale (UPDRS), a scale for assessing autonomic disorders in the patients with PD, statistical analysis with program «Statistica 6.0».
Results. The analysis of the general indicators of gastrointestinal tract disorder in patients during the primary examination and a year later showed a statistically significant difference in the subgroups ІB and ІIB. Statistically significant difference between the total index of cardiovascular autonomic dysfunction a year later was found in patients in the subgroups ІА. The analysis of the general index of autonomic disorders in the dynamics showed a statistically significant difference in the subgroups ІА and ІB.
Conclusions. Morbidity of PD causes not only motor disorders, but also non-motor manifestations, including autonomic disorders. Early diagnosis of premotor disorders makes it possible to identify individuals with an increased risk of developing PD. The important aspect is the conduct of an additional survey to detect concomitant diseases in the patients with progression of PD.##plugins.themes.bootstrap3.article.details##
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.
References
Аленикова О.А. Оценка частоты встречаемости отдельных немоторных симптомов при болезни Паркинсона / О.А. Аленикова, С.А. Лихачев // Медицинские новости. – 2015. – № 10. – С. 52–55.
Иллариошкин С.Н. Болезнь Паркинсона и расстройства движений / Иллариошкин С.Н., Яхно Н.Н. – М.: ООО, Диалог, 2008. – 405 с.
Клинические предикторы болезни Паркинсона / И.В. Черникова, З.А. Гончарова, Х.И. Хадзиева, Е.А. Рабаданова // Кубанский научный медицинский вестник. – 2015 – № 3 (152). – С. 135–139. https://doi.org/10.25207/1608-6228-2015-3-134-139
Exercise hemodynamics in Parkinson’s disease and autonomic dysfunction / D.A. Low, E. Vichayanrat, V. Iodice et al. // Parkinsonism Relat. Disord. – 2014. – V. 20. – P. 549–553. https://doi.org/10.1016/j.parkreldis.2014.02.006
Goldstein D.S. Dysautonomia in Parkinson’s disease / D.S. Goldstein // Compr. Physiol. – 2014. – V. 4. – P. 805–826. https://doi.org/10.1002/cphy.c130026
Goodman B.P., Gupta F. Defining successful treatment of neurogenic orthostatic hypotension with droxidopa in a patient with multiple system atrophy / B.P. Goodman, F. Gupta // Clin. Auton. Res. – 2017. – V. 27. – P. 21–23. https://doi.org/10.1007/s10286-017-0432-8
Natural history of pure autonomic failure: a United States prospective cohort. / H. Kaufmann, L. Norcliffe-Kaufmann, J.A. Palma et al. //Ann. Neurol. – 2017. – V. 81. – P. 287–297. https://doi.org/10.1002/ana.24877
Nonmotor Symptoms in Parkinson’s Disease: The Dark Side of the Moon / Roberto Ceravolo, Carlo Rossi, Lorenzo Kiferle, Ubaldo // Bonuccelli Future Neurology. – 2010. – V. 5 (6). – P. 851–871. https://doi.org/10.2217/fnl.10.69
Palma J.A., Kaufmann H. Epidemiology, Diagnosis and Management of Neurogenic Orthostatic Hypotension / J. A. Palma., H. Kaufmann // Mov. Disord. Clin. Pract. – 2017. – V. 4. – P. 298–308. https://doi.org/10.1002/mdc3.12478
Palma Jose-Alberto. Treatment of Autonomic Dysfunction in Parkinson’s Disease and Other Synucleinopathies / Alberto Palma, Horacio Kaufman // Movement Disorders. – 2018. – V. 33 (3). – P. 372–390. https://doi.org/10.1002/mds.27344
Palma Jose-Alberto. Autonomic disorders predicting Parkinson’s disease / Jose-Alberto Palma, Horacio Kaufmann // Parkinsonism relat. disord. – 2014. – V. 20 (01). – Р. 94–98. https://dx.doi.org/10.1016%2FS1353-8020(13)70024-5
Randomized, controlled pilot trial of solifenacin succinate for overactive bladder in Parkinson’s disease / T.A. Zesiewicz, M. Evatt, C.P. Vaughan et al // Parkinsonism Relat. Disord. – 2015. – V. 21. – P. 514–520. https://doi.org/10.1016/j.parkreldis.2015.02.025
The association between symptoms of sexual dysfunction and age at onset in Parkinson’s disease / T. Ozcan, E. Benli, F. Ozer et al. //Clin. Auton. Res. – 2016. – V. 26. – P. 205–209. https://doi.org/10.1007/s10286-016-0356-8
The prion hypothesis in PD: Braak to the future / Naomi P, Visanji, Patricia L. Brooks, Lili-Naz Hazrati, Anthony E. Lang // Acta Neuropathologica Communications. – 2013 – V. 1, 2. https://dx.doi.org/10.1186%2F2051-5960-1-2
The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension / C.H. Gibbons, P. Schmidt, I. Biaggioni et al. // J Neurol. – 2017. – V. 264. – P. 1567–1582. https://doi.org/10.1007/s00415-016-8375-x
The Movement Disorders Task Force Review of Dysautonomia Rating Scales in Parkinson’s Disease with Regard to Symptoms of Orthostatic Hypotension /Anne Pavy-Le Traon, Gerard Amarenco, Susanne Duerr et al. //Movement Disorders. – 2011. – V. 26 (11). – Р. 1985–1992. https://doi.org/10.1002/mds.23742
