Intergenerational differences in prevalence and association with survival rates of major cardiovascular risk factors
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Abstract
The objective: determination of the prevalence of major cardiovascular risk factors (CVRF) and their association with the survival rate of cardiovascular disease (CVD) among generations 1905–1924 and 1925–1944 years of birth.
Materials and methods. 384 patient case histories were analyzed from 1905 to 1944 with ischemic heart disease (IHD). According to the year of birth, the patients were divided into 2 groups: 1 group – born in the period 1905–1924 («pre-war» generation), 2 group – from 1925–1944 (a generation of «front-line soldiers»). The diagnosis was established on the basis of examinations, in accordance with the current recommendations for the diagnosis of IHD.
Results. There are significant intergroup differences in the frequency and structure of arterial hypertension in the pre-war generation group, the incidence of arterial hypertension (AH) was 64,1%, of which 54,6% is isolated systolic hypertension (ISAH). In the frontline group, the AH frequency reached 74,1%, and ISAG accounted for only 27%. When analyzing the average of low density lipoprotein (LDL) values in the first and second generations, there were no significant differences. However, gender analysis revealed that in both groups of women, the average level of LDL was higher than that of men. The prevalence of elevated LDL in the first generation is higher (98,68%) than in 2 generations (94,12%) (р>0,05). The prevalence of the increased level of glucose in the 1st generation is 4,4%, while in the 2nd generation it increases to 20,6% (p=0,0001). Although the diagnosis of diabetes mellitus is 1,94% in the 1st group and 3,68% in the second group, which indicates a significant increase in the cases of violation of carbohydrate metabolism in the 2nd generation.
Conclusion. Also, with a detailed gender analysis within the group, attention is drawn to the distribution of overweight and obese individuals: if in the 1st generation of overweight men there was more (68,85%) than with obesity (31,15%), and women with increased body weight was 40,38%, with obesity 59,62%, then in 2 generations 61,8% of men were overweight and only 37% obese. In women, a mirror trend was observed – 36,1% were overweight and 63,9% were obese. These CWR factors were associated with various indicators of life. in the first generation there was no dependence of survival on the presence of individual CVR factors; in the second, survival was significantly lower in patients with obesity and hypertension.##plugins.themes.bootstrap3.article.details##
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.
References
Горбась І.М. Епідеміологічна ситуація щодо серцево-судинних захворювань в Україні: 30-річне моніторування // Практична ангіологія. – 2010. – № 9–10. – С. 38–39.
Горбась І.М. Ішемічна хвороба серця: епідеміологія і статистика // Здоров’я України. – 2009. – № 3. – С. 34–35.
Горбась І.М. Фактори ризику серцево-судинних захворювань: куріння // Практична ангіологія. – 2011. – № 7–8. – С. 46–47.
Коваленко В.М., Корнацький В.М. Проблеми здоров’я і тривалості життя в сучасних умовах // Посібник. – 2017. – С. 42–43.
Скляров Є.Я., Максимець Т.А. Фактори ризику і предиктори виникнення ішемічної хвороби серця у жінок // Львівський клінічний вісник. – 2013. – № 4 (4). – С. 52–55.
Arnett DK, Jacobs DR, Jr., Luepker RV, Blackburn H, Armstrong C, Claas SA. Twenty-year trends in serum cholesterol, hypercholesterolemia, and cholesterol medication use: the Minnesota Heart Survey, 1980–1982 to 2000–2002 // Circulation 2005; 112(25): 3884–91. https://doi.org/10.1161/CIRCULATIONAHA.105.549857
Badaruddoza, Raman Kumar, Manpreet Kaur. Principal component analysis of cardiovascular risk traits in three generations cohort among Indian Punjabi population // Journal of Advanced Research 2015; 6: 739–746. https://doi.org/10.1016/j.jare.2014.04.002
Berg CM, Lissner L, Aires N, Lappas G, Toren K, Wilhelmsen L, et al. Trends in blood lipid levels, blood pressure, alcohol and smoking habits from 1985 to 2002: results from INTERGENE and GOTMONICA // Eur J Cardiovasc Prev Rehabil. 2005; 12(2): 115–25. http://dx.doi.org/10.1097/00149831-200504000-00005
Cohen JD, Cziraky MJ, Cai Q, Wallace A, Wasser T, Crouse JR, et al. 30-year trends in serum lipids among United States adults: results from the National Health and Nutrition Examination Surveys II, III, and 1999-2006 // Am J Cardiol 2010; 106(7): 969–75. https://doi.org/10.1016/j.amjcard.2010.05.030
Cutler JA, Sorlie PD, Wolz M, Thom T, Fields LE, Roccella EJ. Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988-1994 and 1999– 2004 // Hypertension 2008; 52(5): 818–27. https://doi.org/10.1161/HYPERTENSIONAHA.108.113357
Eriksson M, Holmgren L, Janlert U, Jansson JH, Lundblad D, Stegmayr B, et al. Large improvements in major cardiovascular risk factors in the population of northern Sweden: the MONICA study 1986-2009 // J Intern Med 2011; 269(2): 219–31. https://doi.org/10.1111/j.1365-2796.2010.02312.x
Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000 // JAMA 2002; 288(14): 1723–7. https://doi.org/10.1001/jama.288.14.1723
Ford ES, Li C, Pearson WS, Zhao G, Mokdad AH. Trends in hypercholesterolemia, treatment and control among United States adults // Int J Cardiol 2010; 140(2): 226–35. https://doi.org/10.1016/j.ijcard.2008.11.033
Gerben Hulsegge, H Susan J Picavet, Anneke Blokstra, Astrid CJ Nooyens, Annemieke MW Spijkerman, Yvonne T van der Schouw, Henriëtte A Smit, WM Monique Verschuren. Today’s adult generations are less healthy than their predecessors: generation shifts in metabolic risk factors: the Doetinchem Cohort Study // European Journal of Preventive Cardiology. Vol 21, Issue 9, 2014. https://doi.org/10.1177%2F2047487313485512
Hajjar I, Kotchen TA. Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988-2000 // JAMA 2003; 290(2): 199–206. https://doi.org/10.1001/jama.290.2.199
Lipscombe LL, Hux JE. Trends in diabetes prevalence, incidence, and mortality in Ontario, Canada 1995-2005: a population-based study // Lancet 2007; 369(9563): 750–6. https://doi.org/10.1016/S0140-6736(07)60361-4
Parikh NI, Pencina MJ, Wang TJ, Lanier KJ, Fox CS, D’Agostino RB, et al. Increasing trends in incidence of overweight and obesity over 5 decades // Am J Med 2007; 120(3): 242–50. https://doi.org/10.1016/j.amjmed.2006.06.004
Peter K. Joshi, Nicola Pirastu, Katherine A. Kentistou, Krista Fischer, Edith Hofer, Katharina E. Schraut, David W. Clark, Teresa Nutile. Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity // Nature Communicationsvolume 8, Article number: 910 (2017) https://doi.org/10.1038/s41467-017-00934-5
Vartiainen E, Laatikainen T, Peltonen M, Juolevi A, Mannisto S, Sundvall J, et al. Thirty-five-year trends in cardiovascular risk factors in Finland // Int J Epidemiol 2010; 39(2): 504–18. https://doi.org/10.1093/ije/dyp330
