Hepsidin: physiological role how central regulator of iron metabolism

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Published: Jan 31, 2017
DOI: https://doi.org/10.30841/2307-5112.1(69).2017.103346
Keywords:
hepsidin, physiological role, iron, homeostasis, metabolism,

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С В. Видиборець
Національна медична академія післядипломної освіти імені П.Л.Шупика МОЗ України, м. Київ, Ukraine
А. О. Андріяка
КЗ КОР «Київський обласний онкологічний диспансер», Ukraine

Abstract

The knowledge about mammalian iron metabolism has advanced dra1 matically over the past decades. Studies of genetics, biochemistry and molecular biology allowed us the identification and characterization of many of the molecules involved in regulation of iron homeostasis. Important progresses were made after the discovery in 2000 of a small peptide – hepsidin – that has been proved to play a central role in orchestration on iron metabolism also providing a link between iron metabolism and inflammation and innate immunity. Hepsidin directly interacts with ferroportin, the only known mammalian iron exporter, which is expressed by enterocytes, macrophages and hepatocytes. The direct hepsidin1 ferroportin interaction allows an adaptative response from the body in situations that alter normal iron homeostasis (hypox1 ia, anemia, iron deficiency, iron overload, and inflammation).

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How to Cite
Видиборець, С. В., & Андріяка, А. О. (2017). Hepsidin: physiological role how central regulator of iron metabolism. Family Medicine, (1(69), 154–157. https://doi.org/10.30841/2307-5112.1(69).2017.103346
Issue
No. 1(69) (2017)
Section
Literature review
Copyright (c) 2020 С В. Видиборець, А. О. Андріяка

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Author Biographies

С В. Видиборець, Національна медична академія післядипломної освіти імені П.Л.Шупика МОЗ України, м. Київ

S.V. Vydyborets

А. О. Андріяка, КЗ КОР «Київський обласний онкологічний диспансер»

A.A. Andriiaka

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