Effects of Neocardil in regulation of cognitive impairment in patients with cardiovascular risk factors
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Abstract
The objective: the aim of the study was to evaluate the influence of phyto pharmacological preparation Neocardil on cognitive function in patients with cardiovascular risk factors at out patient stage.
Patients and methods. Еvaluation of Neocardil efficacy was made during 2 months in 2 group of patients. Each group included 100 patients with such cardiovascular risk factors as hypertension, diabetes mellitus and dyslipidemia. Patients of first group received Neocardil during 2 months and was consulted about hypoglycemic, hypolipi demic diet and physical activity for 30 minutes a day during 3 months. Patients of second group was only consulted about diets and physical activity without Neocardil admission. Office and ambulatory BP measuring and assessment based on Beck, HARS, HDRS, HAM, MMSE, HeartQol scales was made to all patients. Patients condition evaluated before therapy and on 60 th day of therapy.
Results. More patients in Neocardil group achieved target levels of BP at 140/90 mm Hg. Therapy with Neocardil was associated with significant improvement in orientation, perceptive and gnostic func tion, cumulative general score of cognitive productivity. Prevalence of moderate cognitive impairment in Neocardil group decreased by 60% – from 10% to 4%. Decline in score by anxiety scale HARS, depression scales HADS and Beck was noted. Score by HeartQol scale, reflected patients quality of life, also increased in Neocardil group. By HAM scale increase of scores, reflecting general health, activity and mood, was noted.
Conclusion. Therapy with Neocardil is associated with significant improvement in quality of life, cognitive function, decrease and nor malization of anxiety and depression indexes. Neocardil use is also associated with improvement in target levels of blood pressure achievement.
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References
Cooney M.T., Kotseva K., Dudina A., et al. Determinants of risk factor control in subjects with coronary heart disease: a report from the EUROASPIRE III investigators // European Journal of Preventive Cardiology. – 2013. – Vol. 20. – P. 4686–691.
Kotseva K., Wood D., De Backer G., et al. EUROASPIRE III. Management of cardiovascular risk factors in asymptomatic high risk patients in general practice: cross sectional survey in 12 European countries // European Journal of Preventive Cardiology. – 2010. – Vol. 17. – P. 5530–540.
Kotseva K., Wood D., De Backer G., et al. Use and effects of cardiac rehabilitation in patients with coronary heart disease: results from the EUROASPIRE III survey // European Journal of Preventive Cardiology. – 2013. – Vol. 20. – P. 5817–826.
Gyberg V., Kotseva K., Dallongeville J., et al. Does pharmacologic treatment in patients with established coronary artery disease and diabetes fulfil guideline recommended targets? A report from the EUROASPIRE III cross sectional study // European Journal of Preventive Cardiology. – April 1, 2014. 2047487314529353.
Pajak A., Jankowski P., Kotseva K. Depression, anxiety, and risk factor control in patients after hospitalization for coronary heart disease: the EUROASPIRE III Study // European Journal of Preventive Cardiology April. – 2013. – Vol. 20. – Р. 2331–340.
Смулевич А.Б. Депрессии в общей медицине / Руководство для врачей. – М.: Мед. информ. агентство, 2001. – 256 с.
Amit J. Shah et al. Sex and Age Differences in the Association of Depression With Obstructive Coronary Artery Disease and Adverse Cardiovascular Events./ J Am Heart Assoc. 2014 Jun; 3(3): e000741.
Sokoreli I, de Vries JJG, Riistama JM, et al. Depression as an independent risk factor for all cause mortality in heart failure patients. Heart Failure Congress 2015; May 23, 2015; Seville, Spain. Abstract P320.
Meg L., Chen D., Yang Y. et al. Depression increases risk of hypertension incidence: a meta analyses of prospective cohort study// Journal of Hypertension. – 2012. – Vol. 30. – P. 842–851.
World medical association declaration of Helsinki. Ethical Principles for Medical Research Involving Human Subjects. – WMA, 2004 (Хельсинская декларация всемирной медицинской ассоциации. Этические принципы для медицинских исследований с привлечением человека в качестве субъекта испытания. – WMA, 2004).
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts)European Heart Journal (2012) 33, 1635–1701.
Коваленко В.М., О.Г. Несукай, М.М. Долженко, І.М. Горбась. Превентивна кардіологія: імплементація міжнародних рекомендацій в Україні. – К., 2015. – 104 с.
