Disseminated Intravascular Coagulation
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Abstract
Disseminated intravascular coagulation (DIC) is characterized by an acute generalized, widespread activation of coagulation, which results in thrombotic complications, due to the intravascular formation of fibrin, as well as diffuse hemorrhages, due to the consumption of platelets and coagulation factors. In this lecture, we discuss regarding the controversies in diagnosis and management of DIC. Bleeding is a more common manifestation of DIC. We report the present knowledge about the treatment of DIC. Therapy of DIC aims at treating the primary cause. We focus on the current standard treatment of overt DIC in clinical practice. Moreover, particular attention is made to novel therapeutic strategies, who reflect the important progresses in the understanding of the pathogenesis of this syndrome in the last few years.
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References
Bessmeltsev S.S. Sindrom disseminirovanogo vnutrisosudistogo svertyvanija krovi [Disseminated intravascular coagulation]. Ukrajns’kij jurnal gematologiji ta transfusiologiji. no. 2(5). – Р. 43-52.
Clinical oncohematology. A manual for the physician. Ed. by M. A. Volkova. 2nd edition, updated. Moskow: Meditsina Publishers. 1120 p.
Gematologija: nazional’noe rukovodstvo. Ed. by O. A. Rukavitsyn. Moskow: GEOTAR-Media. 776 p.
Gemostaziologija v klinicheskoj i laboratornoj praktike: ucheb. posobije. 2011. Ed by V. S. Kamyshnikov. Minsk: Adukazyja i vyhavanije. – 320 p.
Korkushko O.V., Lishnevs’kaja V.Y. Trombocyty: fiziologija, morfologija, vozrastnyje I patologicheskije osobennosti, antitrombocytarnaja terapija. Kiev: Medkniga. 240 p. (in Russian).
Mamaev A.N. Koagulopatii: rukovodstvo. Moskva: GEOTAR-Media. 264 p.
Makazarija A.D., Bizadze V.O., Akin’shina S.V. Trombozy i tromboembolii v akushersko-ginekologicheskoj praktike: molekuljarno-geneticheskije mechanizmy i strategija profilaktiki tromboembolicheskih oslozhnenij: rukovodstvo dlja vrachej. – M.: OOO «MIA». – 1064 p.
Manual of clinical oncology. Ed. by D. A. Сasciato. Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Kong, Sydney, Tokio: Lippincott Williams & Wilkins A Wolters Kluwer Company. – 1039 p.
Mazurov A.V. Fiziologija i patologija trombozytov. Moskva: Litterra. – 480 p.
Transfusiologija: nazional’noe rukovodstvo. Ed. by A. A. Ragimov Moskva: Izdatel’skaja gruppa «GEONAR-Media», 1184 p.
Usenko L.V., Tsarev A.V., Kobelyatskyy Y.Y., Petrov V.V., Yovenko I.A. 2015. Strategija infizijno-transfusijniji terapiji krovovtraty pry bojovij travmi [Infusion-transfusion strategies in blood loss of the combat trauma]. Gematologija i perelyvannja krovi, no. 38, pp. 322-329.
Usenko L.V., Tsarev A.V., Petrov V.V., Kobelyatskyy Y.Y. Sovremennye principy infuzionno-transfusionnoj terapii krovopoteri pri politravme i protocol massivnoj gemotransfusii [Modern principles of infusion-transfusion therapy in polytrauma blood loss and massive transfusion protocol]. Gematologija. Transfusiologija. Vostochnaja Evropa, no. 1 (01), pp. 64-75.
Zamkovoy A.D., Vydyborets S.V. Praktyka infusijno-transfusijnoji terapiji pry gostryh krovotechah [The acute blood loss and practice of infusion and transfusion therapy]. Gematologija i perelyvannja krovi, no. 38, pp. 150-159.
