Vascular Remodeling in Different Activity of Renin-Angiotenzin-Aldosterone System in Patients with Comorbidity of Arterial Hypertension and Obesity
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Abstract
The objective: the aim of the study was to assess the features of vascular remodeling indifferent activity of the renin-angiotensin-aldosterone system components in patients with arterial hypertension and concomitant obesity.
Materials and methods. We examined 200 patients with arterial hypertension and obesity class I–II who gave informed written consent to participate in the study and met the inclusion criteria.
Results. Comparative assessment of oxidative stress – antioxidant defense of obese patients has shown that when they have low arterial arterial hypertension, the levels of oxidative stress indices are significantly lower, and overall antioxidant protection is significantly higher than with high-renin arterial hypertension.
Conclusion. As a result of the study, it was established that in patients with comorbidity of arterial hypertension and obesity class I–II, low-renin arterial hypertension was associated with less pronounced impairments incertain vascular remodeling parameters (intima-media thickness in the place of the carotid artery bifurcation and pulse wave velocity in the carotid artery), as well as a greater activity of general antioxidant protection and lower activity of oxidative stress indicators such as malonic dialdehyde and diene conjugates.##plugins.themes.bootstrap3.article.details##
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References
Mechanisms of metabolic coronary flow regulation / A. Deussen, V. Ohanyan, A. Jannasch // J. Mol. Cell. Cardiol. – 2012. – Vol. 52, N 4. – Р. 794–801.
Cardiovascular risk assessment beyond Systemic Coronary Risk Estimation: a role for organ damage markers / M. Volpe, A. Battistoni, G. Tocci [et al.] // J. Hypertension. – 2012. – Vol. 30, N 6. – P. 1056–1064.
Insulin resistance аnd hypertension. The Insulin Resistance Atherosclerosis study / M.F. Saad, M. Rewers, J. Selby [et al.] // Hypertention. – 2004. – Vol. 43, N 6. – P. 1324–1331.
Sex differences in predictors of longitudinal changes in carotid artery stiffness: the Multi- Ethnic Study of Atherosclerosis / R. Stern, M.C. Tattersall, A.D. Gepneret al.] // Arteriosclerosis, Thrombosis, and Vascular Biology. – 2015. – Vol. 35, N 2. – Р. 478–484.
Crea F. Coronary microvascular dysfunction: an update / F. Crea, P.G. Camici, C.N. BaireyMerz // Eur. Heart J. – 2014. – Vol. 35, N 17. – Р. 1101–1111.
Metabolic syndrome: is equine disease comparable to what we know in humans? / A. Ertelt, A.-K. Barton, R.R. Schmitz, H. Gehlen //Endocr. Connect. – 2014. – Vol. 3, N 3. – P. R81–R93.
Inflammation and Vascular Remodeling / K-ichi Aihara, Masaki Mogi, Rei Shibata [et al.] // Int. J. Vasc. Med. – 2012. – Vol. 2012. – ID 596796.
Олемпиева Е.В. Окислительный стресс – предиктор начальной стадии гипертонической болезни / Е.В. Олемпиева, А.А. Терновая, В.П. Злобина // Мед. альманах. – 2013. – № 3 (27). – С. 138–139.
Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance / A.R. Aroor, S. McKarns, V.G. Demarco [et al.] // Metabolism. – 2013. – Vol. 62, N 11. – Р. 1543–1552.
Diagnosis and treatment of low-renin hypertension / P. Mulatero, A. Verhovez, F. Morello, F. Veglio //Clin. Endocrinol. – 2007. – Vol. 67. – Р. 324–334.
Sagnella G.A. Why is plasma renin activity lower in populations of african origin? / G.A. Sagnella // J. Hum. Hypertens. – 2001. – Vol. 15. – Р. 17–25.
Kawarazaki W. Aberrant Rac1-mineralocorticoid receptor pathways in saltsensitive hypertension / W. Kawarazaki, T. Fujita//Clin. Exp. Pharmacol. Physiol. – 2013. – Vol. 40. – Р. 929–936.
Adlin E.V. Bimodal aldosterone distribution in low-renin hypertension / E.V. Adlin, L.E. Braitman, R.S. Vasan // Am. J. Hypertens. – 2013. – Vol. 26. – Р. 1076–1085.
Baudrand R. The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor / R. Baudrand, A. Vaidya // Int. J. Mol. Sci. – 2018. – Vol. 19 (546). – Р. 1–15.
