The Significance of Hereditary Factor in the Development of Chronic Kidney Disease (Glomerulonephritis)
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Abstract
The objective: of the research was to evaluate the risk of chronic kidney disease: glomerulonephritis (CKD:GN) development by antigens of blood groups of AB0 and Rhesus (Rh) systems.
Materials and methods. We examined 315 patients (166 men and 149 women) with CKD:GN which manifested by urinary syndrome (US) (asymptomatic proteinuria and/or hematuria). A survey of 1428 healthy individuals was conducted to determine the populational distribution of blood groups phenotypes of AB0 and Rh systems.
Results. The value of the relative risk of CKD:GN with US occurrence in men with phenotype A (II) versus 0 (I) prevailed in 7.79 times the same in women and it was in 5.15 times higher in the latter with phenotype AB (IV) versus A (II) than the same in men. The common feature was a high chance to contract the studied pathology in carriers of phenotype AB (IV) Rh– versus 0 (I) Rh–. Individuals of both genders with group 0 (I) Rh– may be resistant to the development of the disease.
Conclusions. Gender dimorphism consisted in the fact that men with phenotypes AB (IV) Rh– and A (II) Rh– versus 0 (I) Rh–, women with phenotypes AB (IV) Rh– and B (III) Rh– versus 0 (I) Rh– and A (II) Rh– had the highest risk to contract a disease. Somewhat lower risk of disease occurrence was possible in the presence of phenotypes A (II) Rh+ in men and AB (IV) Rh+ in women.##plugins.themes.bootstrap3.article.details##
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