Features of Vascular Remodeling in Patients with Hypertension and Obesity With or Without Insulin Resistance
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Abstract
The objective: the study was to establish the features of vascular remodeling in patients with hypertension and obesity with or without insulin resistance.
Materials and methods. We examined 174 hypertensive patients at the age of 45–55. The first group included 40 patients with normal body weight, the second – 45 patients with overweight, the third – 47 patients with grade I overweight and the fourth – 42 patients with grade II overweight. The control group consisted of 25 practically healthy individuals with normal body weight, comparable in age and gender with the main group.
Results. It has been found that in hypertensive patients, starting from grade I overweight an increase in body mass index is accompanied by an increase in the pulse wave velocity in the carotid artery and a decrease in the degree of endothelium-dependent vasodilation, and grade II overweight is also accompanied by an additional increase in the intimamedia thickness and the pulse wave velocity in the abdominal aorta.
Conclusion. Insulin resistant patients with hypertension have a significantly lower degree of endothelium-dependent vasodilation than hypertensive patients without insulin resistance.##plugins.themes.bootstrap3.article.details##
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.
References
Diabetes and ischemic heart disease: double jeopardy with regard to depressive mood and reduced quality of life / N. Bergmann S. Ballegaard P. Holmager [et al.] // Endocr Connect. –2014. – Vol. 3, N 4. – Р. 156–160.
Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione / Z. Chen, P.A. Vigueira, K.T. Chambers [et al.] // J. Biol. Chem. – 2012. – Vol. 287, N 28. – Р. 23537–23548.
Mechanisms of metabolic coronary flow regulation / A. Deussen, V. Ohanyan, A. Jannasch // J. Mol. Cell. Cardiol. – 2012. – Vol. 52, N 4. –Р. 794–801.
Cardiovascular risk assessment beyond Systemic Coronary Risk Estimation: a role for organ damage markers / M. Volpe, A. Battistoni, G. Tocci[et al.] // J. Hypertension. – 2012. – Vol. 30, N 6. – P. 1056–1064.
Insulin resistance аnd hypertension. The Insulin Resistance Atherosclerosis study / M.F. Saad, M. Rewers, J. Selby [et al.] // Hypertention. – 2004. – Vol. 43, N 6. – P. 1324–1331.
Sex differences in predictors of longitudinal changes in carotid artery stiffness: the Multi-Ethnic Study of Atherosclerosis / R. Stern, M.C. Tattersall, A.D. Gepner[et al.] // Arteriosclerosis, Thrombosis, and Vascular Biology. – 2015. – Vol. 35, N 2. – Р. 478–484.
Майоров А.Ю. Инсулинорезистентность в патогенезе сахарного диабета 2 типа / А.Ю. Майоров // Сахарный диабет. – 2011. – № 1. – С. 35–43.
Crea F. Coronary microvascular dysfunction: an update / F. Crea, P.G. Camici, C.N. BaireyMerz // Eur. Heart J. – 2014. – Vol. 35, N 17. – Р. 1101–1111.
Олемпиева Е.В. Окислительный стресс – предиктор начальной стадии гипертонической болезни / Е.В. Олемпиева, А.А. Терновая, В.П. Злобина // Мед. альманах. – 2013. – № 3 (27). – С. 138–139.
Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance / A.R. Aroor, S. McKarns, V.G. Demarco [et al.] // Metabolism. – 2013. – Vol. 62, N 11. – Р. 1543–1552.
Vasodilator interactions in skeletal muscle blood flow regulation / Y. Hellsten, M. Nyberg, L.G. Jensen, S.P. Mortensen // J. Physiol. – 2012. – Vol. 590, pt 24. – Р. 6297–6305.
Inflammation and Vascular Remodeling / Kichi Aihara, Masaki Mogi, Rei Shibata [et al.] // Int. J. Vasc. Med. – 2012. – Vol. 2012. – ID 596796.
Metabolic syndrome: is equine disease comparable to what we know in humans? / A. Ertelt, A.-K. Barton, R.R. Schmitz, H. Gehlen //Endocr. Connect. – 2014. – Vol. 3, N 3. – P. R81–R93.
Shimamoto K. Metabolic syndrome / K. Shimamoto, T. Miura // Nippon Rinso. – 2009. –Vol. 67 (4). –Р. 771–776.
Lteif A. Endothelin limits insulin action in obese/insulin-resistant humans / A. Lteif, P. Vaishnava, A.D. Baron // Diabetes. – 2007. – Vol. 56. – P. 728–734.
Syed AbdusSaboorAftab. Thickness of the intima media as a new correlate for atherosclerosis risk factors in Indian type 2 diabetes patients / Syed AbdusSaboorAftab // International Journal of Diabetes Mellitus. – 2009. – Vol. 1, iss.1. – P. 7–10.
