The influence of symptoms of debut on course of multiple sclerosis in the context of comorbidity
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Abstract
Despite the long term study of multiple sclerosis (MS) and the successes achieved, an increase in the prevalence of MS in the world shows that many of the issues of this pathology have not been completely solved: first of all, it concerns the risk factors, pathogenesis, the effectiveness of treatment and rehabilitation approaches.
The objective: to analyze the symptoms of MS patients debut and their prognostic value on the course of the disease in the aspect of comorbidity.
Materials and methods. Anamnestic data of 216 MS patients were analyzed for neurologic disorders at the onset of the disease; distribution of patients depending on the month of birth (MH) and depending on the season and month of MS debut.
Results. An analysis of neurologic disorders at the onset of the disease was performed: in 171 (79,2%) patients, the PC debut was monosymptomatic, and in 45 (20,8%) patients multifocal symptoms were identified as the first manifestations of the disease.
Conclusions. In the PC debut, the most frequent sign of the progres sive course was motor (26,1%), sensitive (14,3%) and oculomotor (9,1%) violations; The signs of remission were visual disturbances (23,0%) and polysymptomatic disorders (18,0%).
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References
Дифференциально диагностические критерии неблагоприятного прогноза при прогредиентных типах течения рассеянного склероза / Василовский В.В., Волошина Н.П., Негреба Т.В., Киржнер В.М. // Український вісник психоневрології. – Том 25, випуск 1 (90). – 2017. – С. 71–72.
Негрич Т., Оринчак Л. // Особливості перебігу розсіяного склерозу в жінок залежно від народження дітей. – Міжнар. неврол. журнал. – 2015. – No 5 (75). – С. 45–52.
Чуприна Г.М. Аналіз коморбідності та чинників стилю життя у хворих з розсіяним склерозом / Г.М. Чуприна, Н.К. Мурашко // Сімейна медицина. – 2013. – No 5 (49). – С. 81–85.
Чуприна Г.М. Підхід до рефлексотерапії в комплексному лікуванні хворих з розсіяним склерозом з урахуванням коморбідності / Г.М. Чуприна, Н.К. Мурашко // Сімейна медицина. – 2013. – No 4 (48). – С. 77–80.
Fiddes B. Confounding in association studies: month of birth and multiple sclerosis [Електронний ресурс] / B. Fiddes, J. Wason, S. Sawcer // J. neurol. – 2014. – Vol. 261, No 10. – Р. 1851–1856. – Режим доступу до журн.: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192561/.
Higher relative risk for multiple sclerosis in a рediatric and adolescent diabetic population: analysis from DPV database / S. Bechtold, A. Blaschek, K. Raile [et al.] // Diabetes care. – 2014. – Vol. 37, No 1. – Р. 96–101.
Primer on multiple sclerosis / B.S. Giesser [et al.]; ed. B.S. Giesser. – New York: Oxford university press, 2011. – 463 р.
Season of birth as a risk factor for multiple sclerosis in Brazil / J. Becker, D. Callegaro, M.A. Lana Peixoto [et al.] // Journ. of the neurol. sci. – 2013. – Vol. 329. – Р. 6–10.
Seasonality of birth of patients with juvenile idiopathic arthritis / Y. Berkun, H. Lewy, S. Padeh [et al.] // Clin. and experiment. rheumatol. – 2014. – Р. 2–5.
Summary of evidence based guide line: complementary and alternative medicine in multiple sclerosis [Електронний ресурс] / V. Yadav, C. Bever, J. Bowen [et al.] // Neurology. – 2014. – 82 (12). – Р. 1083–1092. – Режим доступу до журн.: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962995/pdf/NEUROLOGY2013545665.pdf.
Time to secondary progression in patients with multiple sclerosis who were treated with first generation immunomodulating drugs / H. Tedeholm, J. Lycke, B. Skoog [et al.] // Mult. scler. journ. – 2012. – Vol. 19, No 6. – Р. 765–774.
