Influence of three months therapy with L-arginine on the general clinical conditions of patients with various forms of heart failure
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Abstract
The objective: assessing of the impact of the 3 month course of treatment with L arginine on the clinical and functional and laboratory parameters in patients with various forms of heart failure.
Patients and methods. The study included 55 patients with cardiomyopathy: 22 patients with isolated right ventricular dilated cardiomyopathy (RVDCMP) and 33 patients with dilated cardiomyopathy (DCM) with bi ventricular heart failure. The average age of patients 42,1 ± 9,0 year (from 21 to 54 years). Depending on the shape of heart failure patients were divided into two groups. The first group included 22 patients with RVDCMP (average age 45,3 ± 10,2 years), the second included 33 patients with dilated cardiomyopathy (mean age 45,3 ± 13,3 years).
Results. It was noted improvement in clinical and functional and laboratory parameters in both groups of patients, but in the case of RVD CMP these changes were more pronounced in comparison with a group of DCM. Different effects of L-arginine in the analyzed group of patients was caused by the presence of irreversible changes in the state of decompensated myocardium in patients with dilated cardiomyopa thy, while in patients with RVDCMP compensatory response of the heart muscle must have been higher.
Conclusion. The use of arginine in patients with dilated cardiomyopathy with right ventricular or bi-ventricular lesion improves vascular endothelial function, affecting the flow-dependent vasodilatation.
##plugins.themes.bootstrap3.article.details##
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.
References
Лейдерман Н.Н. Иммунное питание (immunonutrition) // Вестн. интенсивной терапии. – 2002. – No 1. – С. 57–61.
Daly J.M., Lieberman M.D., Goldfine J. et. al. Enleral nutrition with supplemental argi nine, RNA, and omega 3 fatty acids in patients after operation: immunologic, metabolic and clinical outcome // Surgery. – 1992. – 112. – P. 56–67.
Darmaun D., Matthews D.E., Bier D.M. Glutamine and glutamate kinetics in humans //Am. J. Physiol. – 151. – P. 117–126.
Степанов Ю.М., Кононов И.Н., Журбина А.И., Филиппова А.Ю. Аргинин в медицинской практике (обзор литературы) / Журн. АМН України. – 2004. – Т. 10, No 1. – С. 340–352.
Катеринчук И.П. Кардиальные эффекты аргинина и эффективность кардиоаргинина при сердечно сосудистой патологии // Здоров’я України. – No 3–4. – С. 76.
Bednarz B, Jaxa Chamiec T, Maciejewski P, Szpajer M, Janik K, Gniot J, Kawka Urbanek T, Drozdowska D, Gessek J, Laskowski H. Efficacy and safety of oral l arginine in acute myocardial infarction. Results of the multicenter, randomized, double blind, placebo controlled ARAMI pilot trial // KardiolPol. – 2005. – 62 (5). – Р. 421–427.
Roe N.D, Ren J. Nitric oxide synthase uncoupling: a therapeutic target in cardiovascular diseases //VasculPharmacol. – 2012, Nov Dec 57 (5-6): 168–72. doi: 10.1016/j.vph.2012.02.004.
Курбанов Р.Д., Абдуллаев Т.А., Ахматов Я.Р. Клинико-гемодинамические проявления правожелудочковой дилатационной кардиомиопатии. Сердечная недостаточность. – 2012. – No 4. – С. 228–232.
Коноплева Л.Ф., Кушнир Л.В. Оценка эффективности применения L-аргинина при легочной артериальной гипертензии различного генеза. www.umj.com.ua/ УКР. МЕД. ЧАСОПИС, 1 (93) – I/II 2013.
Evans М.А., Shronts Е.Р. Intestinal fuels: glutamine, short chain acids, and dietary fibre // J. Am. Diet. Ass. – 1992. – 92. – P. 1239–1246.
Beaux de A.C., O’Riordain M.G., Ross J.A. et al. Glutamine supplemented total parenteral nutrition reduces blood mononuclear cell interleukin 8 release in severe acute pancreatitis // Nutrition. – 1998. – 14, No 3. – P. 261–265.
Белоус А.М., Малахов В.А. Клеточные механизмы сосудистой патологии (обзор литературы) // Журн. АМН України. – 1998. – 4, No 4. – С. 581–596.
Кургалюк Н.М., Ткаченко Г.М., Іккерт О.В. Функцiонування мiтохондрiй за умов iонiзуючого опромiнювання: ефект iнтервальної гiпоксiї та L аргiнiну // Мед. хiмiя. – 2003. – No 1. – С. 18–21.
Bai Y., Sun L., Yang T. et al. (2009) Increase in fasting vascular endothelial function after short term oral L- arginine is effective when baseline ?ow mediated dilation is low: a meta analysis of randomized controlled trials. Am. J. Clin. Nutr., 89 (1): 77–84.
