Autologous platelet plasma: promising method in the osteoarthritis treatment
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Abstract
The investigations of the platelet derived biologic agents in osteoarthritis treatment had shown promising but often con troversial results.
The objective: to study the efficacy and safety of the PAP use in knee OA (stages I II) treatment.
Patients and methods. Study included 146 patients with I II stages of knee OA who were divided into 2 groups: group 1 (68 persons) received standard treatment plus 3 weekly intra artic ular injections of APP (total 2 courses in 12 months); group 2 (78 patients of comparable age and stage of OA) – received only standard OA treatment. All participants underwent clinical, X ray and OA questionary (WOMAC) assessments.
Results. Patients from group 1 demonstrated better results in WOMAC and less frequent exacerbations of OA in 12 month than patients from group 2.
Conclusion. Repeated intraarticular APP injections lead to better results of knee OA treatment and decrease number of OA exacerbations in 12 months.
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http://www.hindawi.com/journals/mi/2010/174341/fig
Clinical and MRI outcomes after platelet rich plasma treatment for knee osteoarthritis /B. Helpern, S. Chaudhury, S.A. Rodeo [et al.]//Clin J Sport Med. – 2013. – No 23 (3). – Р. 238–239.
EULAR Recommendations 2013: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT) / K.M. Jordan, N.K. Arden, M. Doherty [et al.] // Ann Rheum Dis, Publish Online First: 21 July 2013; 62: 1145–1155.
Infiltration of plasma rich in growth factors for osteoarthritis of the knee short term effects on function and quality of life /A. Wang Saegusa, R. Cugat, O. Ares [et al.] //Arch Orthop Trauma Surg. – 2010. – No 131. – Р. 311–317.
Injection of platelet rich plasma in patients with primary and secondary knee osteoarthritis /S. Sampson, M. Reed, H. Silvers [et al.]//Am J of Physical Med & Rehab. – 2010. – No 89. – Р. 961–969.
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