Influence of the Plant-citrate Complex on Indicators of Systemic Inflammation in Patients with Urolithiasis

Authors

  • Olena Karpenko Kyiv City Center of Nephrology and Dialysis, Bogomolets National Medical University
  • Anna Petrova Kyiv City Center of Nephrology and Dialysis, Bogomolets National Medical University

DOI:

https://doi.org/10.30841/2307-5112.5-6.2020.225332

Keywords:

markers of inflammation, herbal citrate complex, urolithiasis, chronic kidney disease, cytokines, Uriklar

Abstract

Treatment of urolithiasis is a complex task of modern medicine. The search for non-invasive methods of treatment, prevention of relapses and complications, slowing down the development of renal failure is an urgent issue of our time. The study demonstrated a comprehensive analysis of indicators of systemic inflammation in patients with urolithiasis and the effectiveness of using the plant-citrate complex.

The objective: to conduct a clinical assessment of systemic inflammation in patients with urolithiasis, to determine the effectiveness of the use of the plant-citrate complex of the drug Uriklar on the indicators of systemic inflammation.

Materials and methods. There were examined 52 (55.6 %) patients with urolithiasis, which were divided into two groups: Group I (main group) – 32 patients with urolithiasis who received the herbal citrate complex and Group II (comparison group) – 20 patients with urolithiasis. The control group included 20 almost healthy individuals. All patients underwent clinical and laboratory tests: general and biochemical blood tests to determine the parameters of iron metabolism, lipid profile, CRP, determination of the levels of cytokines in the blood, blood pressure, body mass index.

Results. The results of this study demonstrate the development of systemic inflammation in patients with urolithiasis, determined by a decrease in GFR. Against the background of the treatment with Uriklar, a decrease in the levels of pro-inflammatory cytokines, CRP and ferritin is observed, which indicates the anti-inflammatory properties of the drug.

Conclusion. Such properties of the plant-citrate complex are pathogenetically substantiated and can be recommended for urolithiasis, which, along with the therapeutic properties, allows to obtain the provision of metaphylaxis of urolithiasis and to slow down the rate of development of chronic kidney disease.

Author Biographies

Olena Karpenko, Kyiv City Center of Nephrology and Dialysis, Bogomolets National Medical University

Olena V. Karpenko,

Department of Propedeutics of Internal Medicine No 2

Anna Petrova, Kyiv City Center of Nephrology and Dialysis, Bogomolets National Medical University

Anna S. Petrova,

Department of Propedeutics of Internal Medicine No 2

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Published

2021-03-15

Issue

Section

For practicing physicians