Obesity and Cardio-vascular Disorders: Review

В. В. Горбачова, О. І. Плегуца


The article reviews an association between increased body mass index and obesity and cardio vascular abnormalities. It is proven, that patients with excess body weight and obesity develop hemodynamic, structural, functional heart and blood vessels disorders, which increase the risk of hypertension, atrial fibrillation, coronary heart disease, chronic heart failure, stroke and increase the risk of death from cardiovascular diseases. Currently, there is an ongoing discussion in the global medical community regarding the existence of such definitions as «metabolically healthy phenotype of obesity», «obesity paradox», «obesity cardiomyopathy». According to modern concepts «metabolically healthy obesity» is considered only as a transition state between a normal metabolically healthy state and metabolically unhealthy obesity. The «obesity paradox» states that patients with chronic heart failure and excess body weight or obesity have a better survival prognosis compared to patients with normal or low body mass index. Therefore, weight loss is not recommended in such patients. However, there are controversial questions regarding the reason for the difference in «obesity paradox» survival. Also, the question remains unclear whether isolated obesity can lead to «obesity cardiomyopathy» due to the lipids accumulation in cardiomyocytes, inflammation, neurohormonal and cellular disorders. It is important to understand the above conditions in order to have a clear idea if there is a need for a therapeutic management. An indisputable tactic is to prevent weight gain and obesity in order to prevent cardiovascular and metabolic diseases. With existing obesity, different treatment options are offered, one of the effective treatment option is a bariatric surgery treatment.


body mass іndex; obesity; «obesity paradox»; cardio-vascular disease; heart failure; metabolіcally healthy obesity; obesity cardіomіopathy


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