The Influence of Combined Therapy on Lipid, Glucose Profile in Patients with Diabetes Mellitus Type II
Keywords:diabetes mellitus type II, Insuvit, diabetic polyneuropathy
According to the International Federation of Diabetes, 7% of the population of the world suffers from diabetes. Optimizing the treatment of diabetes with herbal medicines will reduce the patient’s drug burden.
The objective: the aim of the study was to assess the efficacy of combined treatment with the complex vitamin-herbal pills Insuvit, Metformin and Atorvastatin in patients with diabetes mellitus type II.
Materials and methods. 69 patients (women – 44, men – 25) were treated with diabetes mellitus type II in the therapeutic department of the University Hospital of the ESMC «University Clinic». The average age was 63,4±7,82 years, the duration of diabetes – 7,0±4,11 years. Fasting blood glucose levels, glycosylated hemoglobin (HbA1c), lipid profile were determined onset. Patients were randomized on 2 groups: the main group – 33 patients, who received additionally Insuvit (1 tablet twice a day) for 12 weeks to standard therapy (20 mg of Atorvastatin, 1000 mg of Metformin). Control – 36 patients with similar therapy, but without the appointment of Insuvit.
Results. The levels of HbA1c (by 10,7%), glucose (by 14,7%) and triglycerides (by 35,4%) (p<0,05) significantly decreased after 12 weeks therapy in the main group in comparison with control group. In 39,4% patients of the main group there was s decrease in the sensation of paresthesias, which led to an improvement in overall well-being.Conclusions. The additional use of the drug Insuvit accelerates the compensation of glucose and HbA1c levels in patients with diabetes mellitus type II, which allows them to reach their target levels more quickly.
Amy P. Campbell. Diabetes and Dietary Supplements // Clinical diabetes. – 2010. – Vol. 28, 1: 35–39 https://doi.org/10.2337/diaclin.28.1.35
Nutrition Recommendations and Interventions for Diabetes. A position statement of the American Diabetes // Association Diabetes Care 2008 Jan; 31(suppl. 1): S61-S78. https://doi.org/10.2337/dc08-S061
Глобальный доклад по диабету ВОЗ, 2016 г. PDF
IDF Global Guideline for Managing Older People with Type 2 Diabetes. PDF
Inzucchi S.E., Bergenstal R.M., Buse J.B. et al. Management of Hyperglycemia in Type 2 Diabetes, 2015: a Patient-centred Approach. Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes // Diabetes Care 2015 Jan; 38(1): 140–149. https://doi.org/10.2337/dc14-2441
American Diabetes Association Standards of medical care in diabetes – 2016. PDF
Valdés-Ramos R., Guadarrama-López A.L., Martínez-Carrillo B.E., Benítez-Arciniega А.D. Vitamins and Type 2 Diabetes Mellitus // Endocr Metab. Immune Disord. Drug Targets. – 2015. – Mar. – 15 (1): 54–63. https://doi.org/10.2174/1871530314666141111103217
Arjuna B. The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials Medagama corresponding author // Nutr. J. – 2015. – Vol. 14: 108. https://doi.org/10.1186/s12937-015-0098-9
Chung-Huang Tsai, E.Chin-Fun Chen, Hsin-Sheng Tsay, Ching-jang Huang. Wild bitter gourd improves metabolic syndrome: A preliminary dietary supplementation trial // Nutr. J. – 2012. – Vol. 11. – Р. 4. https://dx.doi.org/10.1186%2F1475-2891-11-4
Raynold V. Yin, Olivia J. Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus // Nutr J. 2015. – Vol. 14. – Р. 14. https://doi.org/10.1186/1475-2891-14-14
Esfandiar Heidarian, Massoud Amini, Mahmoud Parham, Ashraf Aminorroaya. Effect of Zinc Supplementation on Serum Homocysteine in Type 2 Diabetic Patients with Microalbuminuria // Rev Diabet Stud. – 2009. – Vol. 6(1). – Р. 64–70. https://dx.doi.org/10.1900%2FRDS.2009.6.64
Farrokhian A., Bahmani F., Taghizadeh M., Mirhashemi S.M., Aarabi M.H., Raygan F., Aghadavod E., Asemi Z. Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease // Horm Metab Res. 2016. – Apr; 48 (4). – Р. 263–268. https://doi.org/10.1055/s-0035-1569276
Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens // PLoS One. – 2015. – Vol. 10(12). – Р. e0141641. https://doi.org/10.1371/journal.pone.0141641
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