The Modern Face of Celiac Disease. What Should an Internist Know?

Н. Р. Матковська, Л. В. Глушко, Т. Ю. Гавриш, Н. М. Волошинович, Л. М. Скрипник, У. І. Маслій


The World Gastroenterology Organization regards celiac disease as a chronic multicomponent autoimmune disease of the predominantly proximal small intestine, which develops with the use of products containing gluten. Celiac disease is difficult to diagnose due to the multisymptomatic course that can change throughout life. Celiac disease is inherited in an autosomal dominant manner with incomplete penetrance. There are new approaches to the treatment of celiac disease, based on some immune pathogenetic links. In particular, the ways of influencing the intraluminal digestion of gluten, the improvement of barrier functions, the effectiveness of immunomodulators are being studied. Patients should be advised to carefully check the contents of the ingredients before purchasing products. 


celiac disease; gluten-free diet; monitoring the effectiveness of treatment


Гастроентерологія: підручник у 2-х томах / За ред. Харченко Н.В., Бабака О.Я. –Кіровоград: Поліум, 2017. – Т. 2. – С. 27–41.

Дієтологія: Підручник / Н.В. Харченко, Г.А. Анохіна та ін. – К.: «Меридіан», 2012. – С. 195–199.

Окороков А.Н. Руководство по лечению внутренних болезней: т. 2. Лечение болезней органов пищеварения. Лечение болезней пищевода, желудка, кишечника /А.Н. Окороков. – М.: Мед. лит., 2009. – С. 531–542.

Catassi C, Fasano A. Coeliac disease. The debate on coeliac disease screening – are we there yet? Nat Rev Gastroenterol Hepatol 2014;11(8):457–8.

Chmielewska A, Pieścik-Lech M, Szajewska H, Shamir R. Primary prevention of celiac disease: environmental factors with a focus on early nutrition. Ann Nutr Metab 2015;67 Suppl 2:43–50.

Ivarsson A., Myléus A., Norström F., van der Pals M., Rosén A., Högberg L., Danielsson L., Halvarsson B., Hammarroth S., Hernell O., et al. Prevalence of childhood celiac disease and changes in infant feeding. Pediatrics. 2013;131: e687–e694.

Jonas F. Ludvigsson, Carolina Ciacci, Peter HR Green, Katri Kaukinen, Ilma R. Korponay-Szabo et al. Outcome measures in coeliac disease trials: the Tampere recommendations. GUT. 2018; 67(8): 1410–1424.

Jonas F. The Oslo definitions for coeliac disease and related terms / Jonas F., Daniel A., Leffler, Bai Julio [et al.] // Gut. – 2013. – 62(1): 43–52.

Jordan NE, Li Y, Magrini D, et al. Development and validation of a celiac disease quality of life instrument for North American children. J Pediatr Gastroenterol Nutr 2013; 57:477–86.

Julio C. Bai, Carolina Ciacci, Gino Roberto Corazza et al. WGO Global Guidelines Celiac disease (long version). – Oslo, 2016; 35. PDF

Mearin ML. The prevention of coeliac disease. Best Pract Res Clin Gastroenterol 2015;29(3):493–501.

Nordyke K, Norström F, Lindholm L, et al. Health-related quality of life in adolescents with screening-detected celiac disease, before and one year after diagnosis and initiation of gluten-free diet, a prospective nested case-referent study. BMC Public Health 2013; 13:142

Pinto-Sanchez MI, Verdu EF, Gordillo MC, Bai JC, Birch S, Moayyedi P, et al. Tax-deductible provisions for glutenfree diet in Canada compared with systems for gluten-free diet coverage available in various countries. Can J Gastroenterol Hepatol 2015;29(2):104–10.

Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol 2013;108(5):656–76.

Rubio-Tapia A, Murray JA. Classification and management of refractory coeliac disease. Gut 2010;59(4):547–57.

Szajewska H, Shamir R, Mearin L, Ribes-Koninckx C, Catassi C, Domellof M, et al. Gluten introduction and the risk of coeliac disease: a position paper by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2016;62(3):507–13.

Vriezinga SL, Farih N, van der Meulende Jong AE, et al. Comparison of patients’ and doctors’ reports on health-related quality of life in celiac disease. J Pediatr Gastroenterol Nutr 2017; 64:737–41.

Pico M, Spirito MF. Implementation of a health-related quality of life questionnaire for children and adolescents with celiac disease. Arch Argent Pediatr 2014; 112:19–25.

Copyright (c) 2020 Н. Р. Матковська, Л. В. Глушко, Т. Ю. Гавриш, Н. М. Волошинович, Л. М. Скрипник, У. І. Маслій

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

ISSN 2412-8708 (Online), ISSN 2307-5112 (Print)

Flag Counter

ISSN (print): 2307-5112.