Features of autonomic dysfunction in the patients with Parkinson’s disease on the background of autoimmune pathology


Т. О. Чеборака


Dysautonomia is a common occurrence in PD and is probably due to the neurodegenerative disease process itself, taking place inside either the CNS or peripheral postganglionic neurons.

The objective: to investigate the clinical manifestations of autonomic disorders in the patients with PD on the background of autoimmune thyroiditis (AIT).

Materials and methods. 109 patients with PD at the age from 47 to 75 years were examined. The main group of patients consisted of ІА and ІB subgroups, control group – ІІА and IIB. Conducted general clinical and neurological examination, assessment of motor functions using the unified PD rating scale (UPDRS), a scale for assessing autonomic disorders in the patients with PD, statistical analysis with program «Statistica 6.0».

Results. The analysis of the general indicators of gastrointestinal tract disorder in patients during the primary examination and a year later showed a statistically significant difference in the subgroups ІB and ІIB. Statistically significant difference between the total index of cardiovascular autonomic dysfunction a year later was found in patients in the subgroups ІА. The analysis of the general index of autonomic disorders in the dynamics showed a statistically significant difference in the subgroups ІА and ІB.

Conclusions. Morbidity of PD causes not only motor disorders, but also non-motor manifestations, including autonomic disorders. Early diagnosis of premotor disorders makes it possible to identify individuals with an increased risk of developing PD. The important aspect is the conduct of an additional survey to detect concomitant diseases in the patients with progression of PD.


How to Cite
Чеборака, Т. О. (2018). Features of autonomic dysfunction in the patients with Parkinson’s disease on the background of autoimmune pathology. Family Medicine, (3), 75–80. https://doi.org/10.30841/2307-5112.3.2018.146693
Author Biography

Т. О. Чеборака, P.L. Shupyk National Medical Academy of Postgraduate Education

Tetiana O. Cheboraka,

Department of Neurology № 1


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