DOI: https://doi.org/10.30841/2307-5112.2.2018.145642

Effect of Tivorel on the level of matrix metalloproteinases-2 and 9, galectin-3, final glycation products and functional state of the endothelium in patients with postinfarction chronic heart failure with preserved ejection fraction

О. В. Курята, А. Забіда, О. Ю. Сіренко

Abstract


The objective: to evaluate the effect of Tivor-L (20 mg levocarnitine + 42 mg arginine hydrochloride, Yuriya-Pharm) on AGEs, galectin-3, MMP-2,9 serum level, cardiac haemodynamics and endothelial function in patients with post infarction HFpEF.

Materials and methods. All individuals (35) included aged 40 to 80 years, 23 (66%) males and 12 (34%) females were diagnosed with (HFpEF) according to ESC guidelines (2016). First (1-st ) group (n=15) pts with postinfarction HFpEF treated with Tivor-L in addition to standard treatment for Chronic heart failure (CHF). Second (2nd) group (n=20) – pts with postinfarction HFpEF with standard treatment for CHF without Tivor-L. All the patients included in 1st group got Tivor-L intravenously daily for 10 days in addition to the conventional therapy. General biochemical blood analysis, complete blood count and glomerular filtration rate, MMP-2, MMP-9, galectin-3 and AGEs serum levels were determined before and after treatment.

Results. Mean galectin-3 level in 1st was decreased by 16.4 % on the whole (p<0,05), in compare with standard therapy – no significant changes (p>0,05). significant decreasing of MMP-2, MMP-9 levels on 41% and 78,5% in 1st group (p<0,05). The FMD level was significantly higher in 1st group than in standard therapy group (p<0,05). Endothelial function normalizing was achieved in 10 (66%) of 1st group patients.

Conclusion. Most of the pts with postinfarction HFpEF have increased AGEs serum level, and endothelial dysfunction. There were a significant decrease in galectin-3 and MMP-2, MMP-9 serum levels after adding of Tivor-L to the conventional treatment for chronic heart failure.

Keywords


postinfarction heart failure; matrix metalloproteinase; galectin-3

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