State of systemic inflammation in patients with psoriatic disease of moderate severity of concomitant metabolic syndrome
Keywords:psoriasis, metabolic syndrome, systemic inflammation
AbstractClinical and laboratory studies conducted in 40 patients with uncom plicated widespread plaque psoriasis, the stationary phase, the average degree of severity with concomitant metabolic syndrome. Suggest that in patients with concomitant psoriasis MS plays an important role sys temic inflammatory process that is accompanied by the development of insulin resistance (IR), lipid and nitrogen metabolism, regulation of vascular tone. Processes of systemic inflammation and IR in patients with psoriasis and MS may be potential targets of complex therapy.
Беловол А.Н. Дисфункция сосудистого эндотелия у больных псориазом // Укр. журн. дерматол., венерол., косметол. – 2010. – No 1 (36). – С. 17–21.
Писаржевский С.А. Проницаемость эндотелия и атеросклероз // Кардиология. – 2005. – No 12. – С. 27–42.
Ткаченко С.Г., Кондрашова В.Б. Кардиометаболический риск у больных псориазом // Дерматол. та венерол. – 2010. – No 2 (48). – С. 11–17.
Шмакова А.С. Роль липидных нарушений и провоспалительных цитокинов в патогенезе и их коррекция: Автореф. дис. ... канд. мед. наук. – М., 2009. – 18 с.
Chodorowska G, Wojnowska D, Juszkiewicz Borowiec M (2004) C reactive protein and alpha2 macroglobulin plasma activity in medium severe and severe psoriasis. J Eur Acad Dermatol Venerol 18:180–183.
Henseler T, Schmitt Rau K. A comparison between BSA, PASI, PLASI and SAPASI as measures of disease severity and improvement by therapy in patients with psoriasis // Int J Dermatol. 2008; 47(10):1019–23.
Hotamisligil Gs (2006) Inflammation and metabolic disorders. Nature 444:860–867.
Hansson GI (2005) Inflammation, atherosclerosis and coronary artery disease. N Engl J Med 52:1685–1695.
Ludwig RJ, Schultz JE, Boehncke W H et al (2004) Activated, not resting, platelets increase leukocyte rolling in urine skin utilizing a distinct set of adhesion molecules. J Invest Dermatol 122:830–836.
Mallbris L, Granath F, Hamsten A, Stahle M (2006) Psoriasis is associated with lipid abnormalities at the onset of skin disease. J Am Acad Dermatol 54:614–621.
Pereira M.G. Dyadic adjustment, family coping, body image, quality of life and psychological morbidity in patients with psoriasis and their partners./ M.G. Pereira, L. Brito., T. Smith // Int. J. Behav. Med. – 2011 – Jun 25.
Rocha Pereira P, Santos Silva A, Rebelo I et al (2004) The inflammatory respons in mild and in severe psoriasis. Br J Dermatol 150:917–928.
Reich K. The concept of psoriasis as a systemic in?ammation: implications for disease management. JEADV 2012, 26 (Suppl. 2), 3–11.
Schfer T (2006) Epidemiology of psoriasis – review and the German perspective. Dermatology 212: 327–337.
Sommer D., Jenisch M., Suchan M. Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis // Arch. Dermatol. Res. – 2006. – Vol. 298, No 7. – P. 321–328.
Späh F. Inflammation in atheroscle rosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach // Br. J. Dermatol. – 2008. – Vol. 159, Suppl 2. – Р. 10–17.
Sabbat R., Philips S., Hoflich C. Immunopathogenesis of psoriasis // Exp. Dermatol. – 2007. – Vol. 16, No 9. – P. 779–798.
Wu Y. Prevalence of cardiovascular risk factors and other comorbidities among psoriasis patients // J. Am. Acad. Dermatol. – 2007. – Vol. 191, No 9. – Р. 23–27.
Copyright (c) 2020 Я. О. Ємченко
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The journal does not require authors of original (primary) research papers to assign the copyright of their published contributions. Authors grant the journal an non-exclusive licence CC BY 4.0 (Creative Commons Attribution 4.0 International License) to using and the first publication of the original in this journal. Copyright of the manuscripts is retained by the authors, after publication authors retain rights to reuse their papers in their future printed work without first requiring permission from the publisher of the journal and share their own published articles.
The journal supports the self-archiving process. Prior to publication in the journal, authors may post a copy of their manuscript in preparation or submitted to the journal in recognized non-commercial preprint servers, public websites. Authors also are encouraged to archive their final author version of the manuscript in their institution's repositories and, if they wish, on their personal websites. Authors should cite the publication reference and DOI number on the first page of any deposited version, and provide a link from it to the URL of the published article on the journal's website.
To facilitate self-archiving of original research papers and help authors fulfil funder and institutional mandates, the journal deposits manuscripts in National Library of Ukraine by V.I. Vernadsky, Scientific periodicals of Ukraine database and different international scintificd database on behalf of authors who opt-in to this free service during submission. The journal provides depositing of articles on official website of the publisher. The full text access to published papers is free.