Main clinical and neuroimaging predictors of disability progression in multiple sclerosis

Authors

  • Т. О. Кобись Київський міській центр розсіяного склерозу; Київська міська клінічна лікарня No 4

DOI:

https://doi.org/10.30841/2307-5112.2(64).2016.102485

Keywords:

relapsing remitting multiple sclerosis, clinically isolated syndrome, disability progression, clinical and neuroimaging factors

Abstract

The objective: identification of the main predictors of progression of disability in patients with multiple sclerosis (MS ) , depending on the clinical and neuroimaging factors.

Patients and methods. The data presented was collected during a ten year observation of 180 patients with relapsing remitting multiple sclerosis (RRRS) from the first clinical signs of the disease (CIS). Age surveyed ranged from 18 to 42 years old with a mean of 31,5 ± 1,18 years . We determined clinical and neuroimaging factors of active dis ease course with development of moderate disability symptoms in dif ferent periods of the study.

Results. High relapse rate in the early years of the disease is significant factor in achieving a moderate level of disability as per EDSS scale in the long run – after 8 to 10 years since onset.

Conclusion. The main neuroimaging predictors of disability progres sion in RRRS is the presence of 9 or more T2 lesions with CIS, sub tentorial and periventricular localization of lesions, and the number of T2 cells ≥3 mm.

Author Biography

Т. О. Кобись, Київський міській центр розсіяного склерозу; Київська міська клінічна лікарня No 4

T.A. Kobys

References

Волошина Н.П., Гапонов И.К. Возможности магнитно -резонансной томографии в диагностике и прогнозе течения рассеянного склероза в зависимости от пола и возраста больных // Український вісник психоневрології. – 2010. – Т. 2, No 3 (64). – С. 19–23.

Ann Yeh E. Multiple sclerosis: predicting risk and delaying progression / Yeh E. Ann, Bianca Weinstock Guttman // Neurology. – 2010. – Vol. 9, No 1. – P. 7–9.

Bar Zohar D. Magnetic resonance imaging metrics and their correlation with clinical outcomes in multiple sclerosis: a review of the literature and future perspectives / D. Bar Zohar, F. Agosta, D. Goldstaub, M. Filippi // Mult. Scler. – 2008. – Vol. 14, No 6. – P. 719–727.

Brex P.A. A longitudinal study of abnormalities on MRI and disability from multiple sclerosis / P.A. Brex, O. Ciccarelli, J.I. O’Riordan [et al.] // N. Engl. J. Med. – 2002. – Vol. 346, No 3. – P. 158–164.

Correale J. Benign multiple sclerosis: a new definition of this entity is needed / J. Correale, I. Peirano, L. Romano // Mult. Scler. – 2012. – Vol. 18, No 2. – P. 210–218.

Fisniku L.K. Disability and T2 MRI lesions: a 20 year follow up of patients with relapse onset of multiple sclerosis / L.K. Fisniku, P.A. Brex, D.R. Altmann [et al.] // Brain. – 2008. – Vol. 131 (Pt 3). – P. 808–817.

Kister I. Disability in multiple sclerosis: A reference for patients and clinicians / I. Kister, E. Chamot, A.R. Salter, G.R. Cutter, T.E. Bacon, J. Herbert // Neurology. – 2013, Mar 12. – Vol. 80, No 11. – P. 1018–1824.

Lovblad K.O. MR imaging in Multiple Sclerosis: review and recommendation for current practice / K.O. Lovblad, N. Anzalone, A. Doflier [et al.] // AJNR Am J Neuroradiol. – 2010. – Vol. 31. – P. 983–989.

Menon S. Characterising aggressive multiple sclerosis / S. Menon, A. Shirani, H. Zhao [et al.] // J. Neurol. Neurosurg. Psychiatry. – 2013. – Vol. 84, No 11. – P. 1192–1198.

Scalfari A. Early relapses, onset of progression, and late outcome in multiple sclerosis / A. Scalfari, A. Neuhaus, M. Daumer, G. Deluca, P. Muraro, G. Ebers // JAMA Neurol. – 2013. – Vol. 70, No 2. – P. 214–222.

Scalfari A. The natural history of multiple sclerosis, a geographically based study. Relapses and long term disability / A. Scalfari, A. Neuhaus, A. Degenhardt [et al.] // Brain. – 2010. – Vol. 133 (Pt 7). – P. 1914–1929.

Tremlett H. UBC Neurologists. Impact of multiple sclerosis relapses on progression diminishes with time / H. Tremlett, M. Yousefi, V. Devonshire, P. Rieckmann, Y. Zhao // Neurology. – 2009. – Vol. 73, No 20. – P. 1616–1623.

Tremlett H. New perspectives in the natural history of multiple sclerosis / H. Tremlett, Y. Zhao, P. Rieckmann, M. Hutchinson // Neurology. – 2010. – Vol. 74, No 24. – P. 2004–2015.

Ziemsenn T., Tintore M.A. New Era in Multiple Sclerosis: New Consideration for Therapeutic Approaches. – Elsevier, 2010. – 94 p.

Published

2016-05-20

Issue

Section

Neurology